{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:17:50Z","timestamp":1777555070979,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Patient Care and STDs"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                    To broaden access to HIV viral load monitoring (VLM), the use of blood samples from dried blood spots (DBS) or point-of-care (POC) devices, could be of great help in settings where plasma is not easily accessible. The variety of assays available makes the choice complex. This systematic review and meta-analysis aims to estimate the sensitivity and specificity of DBS and POC devices to identify patients in virological failure using World Health Organization (WHO) recommendations (viral load \u22651000 copies\/mL), compared with plasma, for the assays currently available. Four databases were searched for articles, and two reviewers independently identified articles reporting sensitivity and specificity of DBS and\/or POC to identify patients in virological failure. We excluded articles that used other thresholds as well as articles with a total number of participants below 50 to avoid reporting bias. Heterogeneity and factors associated with assays' performances were assessed by\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistics and metaregression. The protocol of this review follows the PRISMA guidelines. Out of 941 articles, 47 were included: 32 DBS evaluations and 16 POC evaluations. Overall, when using DBS, the Abbott RT HIV-1, Roche CAP-CTM, NucliSENS BioMerieux and Aptima assays presented sensitivity and specificity exceeding 85%, but reported results were highly heterogeneous. Factors associated with better performances were high volume of blood and the use of the same assay for DBS and plasma VLM. Regarding the POC devices, SAMBA I, SAMBA II, and GeneXpert devices presented high sensitivity and specificity exceeding 90%, with less heterogeneity. DBS is suitable VLM, but performances can vary greatly depending on the protocols, and should be performed in trained centers. POC is suitable for VLM with less risk of heterogeneity but is more intensive in costs and logistics.\n                  <\/jats:p>","DOI":"10.1089\/apc.2022.0135","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:28:32Z","timestamp":1676384912000},"page":"66-83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Performances of Dried Blood Spots and Point-of-Care Devices to Identify Virological Failure in HIV-Infected Patients: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-0868","authenticated-orcid":false,"given":"Liem Binh Luong","family":"Nguyen","sequence":"first","affiliation":[{"name":"Epidemiology of Emerging Diseases, Universit\u00e9 de Paris, Institut Pasteur, Paris, France."},{"name":"Assistance Publique H\u00f4pitaux de Paris (AP-HP), CIC 1417 Cochin Pasteur, H\u00f4pital Cochin, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abou Aissata","family":"Soumah","sequence":"additional","affiliation":[{"name":"Epidemiology of Emerging Diseases, Universit\u00e9 de Paris, Institut Pasteur, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Thuan","family":"Hoang","sequence":"additional","affiliation":[{"name":"Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"National Institute of Health and Epidemiology (NIHE), Hanoi, Vietnam."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thang Hong","family":"Pham","sequence":"additional","affiliation":[{"name":"National Institute of Health and Epidemiology (NIHE), Hanoi, Vietnam."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Royer-Devaux","sequence":"additional","affiliation":[{"name":"CeRIS, Universit\u00e9 de Paris, Institut Pasteur, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-1261","authenticated-orcid":false,"given":"Yoann","family":"Madec","sequence":"additional","affiliation":[{"name":"Epidemiology of Emerging Diseases, Universit\u00e9 de Paris, Institut Pasteur, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"UNAIDS. 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