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Identifying subtypes of PWH with similar patterns of neurocognitive impairment (NCI) and depressive symptoms may inform development of patient-centered interventions that target-specific profiles. This study aimed to (1) classify PWH based on patterns of domain-specific NCI and depression; and (2) determine the relationship between latent class membership and pertinent clinical characteristics. PWH (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    \u2009=\u2009580, 86.2% male, 57.1% non-Hispanic White, 69.2% unemployed) completed a comprehensive neuropsychological test battery assessing global and domain-specific cognition. Domain-specific NCI was classified as deficit score &gt;0.5. Participants completed the Beck Depression Inventory-II (BDI-II), and domain-specific BDI-II scores reflecting cognitive, affective, and somatic symptoms were computed. Latent profile analysis (LPA) was used to determine latent subgroups of NCI and depression. The optimal LPA solution consisted of five classes: minimal NCI and minimal depression (Class 1), amnestic and minimal depression (Class 2), severe multi-domain NCI and moderate depression (somatic and affective; Class 3), mild NCI and mild depression (Class 4), and moderate multi-domain NCI and severe depression (Class 5). Despite similar levels of functional impairment, Class 5 had a significant psychiatric profile, whereas Class 3 had a complex medical profile (i.e., higher frailty index, higher medications, greater proportion of AIDS diagnosis). In contrast, Class 1 had the lowest medication use and frailty index, with similar HIV disease characteristics to Classes 3 and 5. Our results suggest there are multiple pathways to cognitive and functional impairment among PWH with co-occurring depression and cognitive impairment, and these groups may respond differently to interventions. Of note, our sample was majority non-Hispanic White and male, which is nonrepresentative of the US population of PWH. Future interventions should consider a more integrated, person-centered approach that addresses cognitive and emotional health to optimize health outcomes in PWH.\n                  <\/jats:p>","DOI":"10.1089\/apc.2023.0224","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T15:03:26Z","timestamp":1708527806000},"page":"93-106","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Latent Profile Analysis of Cognitive Performance and Depressive Symptoms Among People with HIV"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-9697","authenticated-orcid":false,"given":"Maulika","family":"Kohli","sequence":"first","affiliation":[{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA."},{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-9700","authenticated-orcid":false,"given":"Lillian","family":"Ham","sequence":"additional","affiliation":[{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA."},{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowan","family":"Saloner","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin","family":"Dung","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Iudicello","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA."},{"name":"Department of Psychiatry and University of California, San Diego, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Ellis","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA."},{"name":"Department of Psychiatry and University of California, San Diego, La Jolla, California, USA."},{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Moore","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, California, USA."},{"name":"Department of Psychiatry and University of California, San Diego, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61113-7"},{"key":"e_1_3_5_3_2","unstructured":"Centers for Disease Control and Prevention. 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