{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:22:40Z","timestamp":1793910160960,"version":"4.8.0"},"reference-count":357,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n                    An imbalance in reducing and oxidizing (redox) systems favoring a more oxidative environment is present in asthma and linked to the pathophysiology of the defining symptoms and signs including airflow limitation, hyper-reactivity, and airway remodeling. High levels of hydrogen peroxide, nitric oxide (\n                    <jats:sup>\u2022<\/jats:sup>\n                    NO), and 15-F\n                    <jats:sub>2t<\/jats:sub>\n                    -isoprostane in exhaled breath, and excessive oxidative protein products in lung epithelial lining fluid, peripheral blood, and urine provide abundant evidence for pathologic oxidizing processes in asthma. Parallel studies document loss of reducing potential by nonenzymatic and enzymatic antioxidants. The essential first line antioxidant enzymes superoxide dismutases (SOD) and catalase are reduced in asthma as compared to healthy individuals, with lowest levels in those patients with the most severe asthma. Loss of SOD and catalase activity is related to oxidative modifications of the enzymes, while other antioxidant gene polymorphisms are linked to susceptibility to develop asthma. Monitoring of exhaled\n                    <jats:sup>\u2022<\/jats:sup>\n                    NO has entered clinical practice because it is useful to optimize asthma care, and a wide array of other biochemical oxidative and nitrative biomarkers are currently being evaluated for asthma monitoring and phenotyping. Novel therapeutic strategies that target correction of redox abnormalities show promise for the treatment of asthma.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    12, 93\u2013124.\n                  <\/jats:p>","DOI":"10.1089\/ars.2008.2425","type":"journal-article","created":{"date-parts":[[2009,7,27]],"date-time":"2009-07-27T09:38:46Z","timestamp":1248687526000},"page":"93-124","source":"Crossref","is-referenced-by-count":216,"title":["Redox Control of Asthma: Molecular Mechanisms and Therapeutic Opportunities"],"prefix":"10.1177","volume":"12","author":[{"given":"Suzy A.A.","family":"Comhair","sequence":"first","affiliation":[{"name":"Lerner Research Institute, and the Respiratory Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil C.","family":"Erzurum","sequence":"additional","affiliation":[{"name":"Lerner Research Institute, and the Respiratory Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.48.37524"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5425"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi011206v"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1403"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005643200"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958370600686267"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00278-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2101021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1566OC"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2008.12.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01701.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221269198"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912041"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197803232981205"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197803302981305"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)37225-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.1.25"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(96)84921-2"},{"key":"e_1_3_2_21_2","first-page":"109","article-title":"Superoxide dismutase and catalase","volume":"2","author":"Bartosz G","year":"2005","unstructured":"Bartosz G. Superoxide dismutase and catalase. Handbook Environment Chem, 2 part O:109\u2013149. 2005.","journal-title":"Handbook Environment Chem"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90278-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)49337-8"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.38.24521"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90432-V"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl158"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309046200"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02075"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(84)90125-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112400200"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90014-X"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.27.2.4699"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19580701707"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1074"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0038"},{"key":"e_1_3_2_36_2","first-page":"1173","volume-title":"Allergy, Principles and Practice","author":"Busse WW","year":"1992","unstructured":"Busse WW, , Reed CE. Middleton EJr, , Reed CE, , Ellis EF, , Adkinson NFJr, , Yunginger JW, , Busse WW. Asthma, Definition and Pathogenesis. Allergy, Principles and Practice, volume II. St Louis: Mosby-Year Book, 1992; 1173."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9902064"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.2_Pt_1.317"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80394-A"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02714149"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.2.370"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.1.152"},{"key":"e_1_3_2_43_2","first-page":"519","article-title":"Oxidant and antioxidants in lung injury","author":"Cantin AM","year":"1999","unstructured":"Cantin AM, , Paquette. Oxidant and antioxidants in lung injury. Lam and other Diseases characterized by smooth muscle proliferation, 1999; 519\u2013531.","journal-title":"Lam and other Diseases characterized by smooth muscle proliferation"},{"key":"e_1_3_2_44_2","first-page":"7","article-title":"Oxidants, antioxidants and the pathogenesis of emphysema","volume":"139","author":"Cantin A","year":"1985","unstructured":"Cantin A, , Crystal RG. Oxidants, antioxidants and the pathogenesis of emphysema. Eur J Respir Dis, 139:7\u201317. 1985.","journal-title":"Eur J Respir Dis"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301292200"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.3.1875"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00097.2004"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20070"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0289SM"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(02)00309-3"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.109.2826.204.b"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00919-X"},{"key":"e_1_3_2_54_2","first-page":"29","article-title":"Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs","volume":"73","author":"Chang LY","year":"1995","unstructured":"Chang LY, , Kang BH, , Slot JW, , Vincent R, , Crapo JD. Immunocytochemical localization of the sites of superoxide dismutase induction by hyperoxia in rat lungs. Lab Invest, 73:29\u201339. 1995.","journal-title":"Lab Invest"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072625"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.15.1.8679227"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.004"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/8.5.530"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04736-4"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0085com"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00491.2001"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.72"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9810044"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200502-180OC"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.23.3.4076"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62288-2"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00000-8"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.4.357"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200206-507OC"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.2001108"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200305-659OC"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.6.1112.1112"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10405"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.02.021"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69051936.x"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.11.942"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01484-4"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200804-549OC"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1716"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.06.014"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00929502"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1042\/bss0610001"},{"key":"e_1_3_2_83_2","first-page":"L148","article-title":"Decreased Cu, Zn-SOD activity in asthmatic airway epithelium: Correction by inhaled corticosteroid in vivo","volume":"272","author":"De Raeve HR","year":"1997","unstructured":"De Raeve HR, , Thunnissen FB, , Kaneko FT, , Guo FH, , Lewis M, , Kavuru MS, , Secic M, , Thomassen MJ, , Erzurum SC. Decreased Cu, Zn-SOD activity in asthmatic airway epithelium: Correction by inhaled corticosteroid in vivo. Am J Physiol, 272:L148\u2013154. 1997.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1970.50.3.319"},{"key":"e_1_3_2_85_2","first-page":"L163","article-title":"Regulation of cellular glutathione","volume":"257","author":"Deneke SM","year":"1989","unstructured":"Deneke SM, , Fanburg BL. Regulation of cellular glutathione. Am J Physiol, 257:L163\u2013173. 1989.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00426-5"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00111-2"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1363"},{"key":"e_1_3_2_89_2","first-page":"415","article-title":"Reactive oxygen intermediates as signaling molecules","author":"Downey GP","year":"1997","unstructured":"Downey GP, , Fialkow L. Forman HF, , Cadenas E. Reactive oxygen intermediates as signaling molecules. Oxidative Stress and Signal Transduction, 1997; 415\u2013441.","journal-title":"Oxidative Stress and Signal Transduction"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.5.3166"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)37381-2"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00322.2006"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051629498"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1378"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9903064"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01055.x"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.12.037"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.037283"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.3.1256"},{"key":"e_1_3_2_100_2","first-page":"201","article-title":"Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients: A feasibility study","volume":"49","author":"Escribano A","year":"2002","unstructured":"Escribano A, , Garcia-Grande A, , Montanes P, , Miralles L, , Garcia A. Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients: A feasibility study. Neoplasma, 49:201\u2013208. 2002.","journal-title":"Neoplasma"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00275-2"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308604771978354"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01176-0"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/301715a0"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.3.528"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705632"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118047"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.44.070175.001051"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.210504"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.48.030186.003401"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1908"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90102-0"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55001-8"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.7508323"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07485-0"},{"key":"e_1_3_2_116_2","first-page":"239","volume-title":"The Lung: Scientific Foundations","author":"Gaston B","year":"1997","unstructured":"Gaston B, , Stamler JS. Crystal R, , West J, , Weibel E, , Barnes. Nitrogen oxides and lung function. The Lung: Scientific Foundations, 2nd ed.. Philadelphia: Lippincott Raven, 1997; 239\u2013253.","edition":"2"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23747.x"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.14.2031"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.6.479"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5587"},{"key":"e_1_3_2_121_2","first-page":"A889","article-title":"Nitration of proteins in murine model of asthma","volume":"167","author":"Ghosh S","year":"2003","unstructured":"Ghosh S, , Masri F, , Comhair S, , Andreadis A, , Swaidani S, , Aronica M, , Aulak K, , Erzurum S. Nitration of proteins in murine model of asthma. Am J Respir Crit Care Med, 167:A889. 2003.","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112065"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1030"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234749"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408449509089886"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.40.28233"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.11.5970"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.7809"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106s51119"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119598"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520250129"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00717.x"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92211-X"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86093-B"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235362"},{"key":"e_1_3_2_136_2","first-page":"H1217","article-title":"Studies of functional site of origin of native coronary collaterals","volume":"251","author":"Harrison DG","year":"1986","unstructured":"Harrison DG, , Chapman MP, , Christy JP, , Marcus ML. Studies of functional site of origin of native coronary collaterals. Am J Physiol, 251:H1217\u20131224. 1986.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9706116"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)00117-2"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.10.950"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.2.531"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5294"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.027"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71625-6"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.60.2.285"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)01165-5"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1936"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1620"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770909709071205"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7311"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9911005"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0331390"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071054698"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2003145"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.768"},{"key":"e_1_3_2_155_2","unstructured":"Institute NNhlab. National asthma eduction and prevention program. Expert panel report 2:Guidelines for the diagnosis and management of asthma. 1997; 4051p. Publication no. 97."},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.099366"},{"issue":"2","key":"e_1_3_2_157_2","first-page":"52","article-title":"Effects of environmental tobacco smoke on the respiratory health of adults","volume":"28","author":"Jaakkola MS","year":"2002","unstructured":"Jaakkola MS, , Jaakkola JJ. Effects of environmental tobacco smoke on the respiratory health of adults. Scand J Work Environ Health, 28,Suppl 2:52\u201370. 2002.","journal-title":"Scand J Work Environ Health"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00001306"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07214-2"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.4.905"},{"key":"e_1_3_2_161_2","first-page":"131","article-title":"Enhanced production of oxygen radicals in asthma","volume":"123","author":"Jarjour NN","year":"1994","unstructured":"Jarjour NN, , Calhoun WJ. Enhanced production of oxygen radicals in asthma. J Lab Clin Med, 123:131\u2013136. 1994.","journal-title":"J Lab Clin Med"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9806170"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.6.714"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.3.746"},{"key":"e_1_3_2_165_2","first-page":"75","article-title":"Bronchial hyper-responsiveness of women with asthma exposed to environmental tobacco smoke","volume":"41","author":"Jindal SK","year":"1999","unstructured":"Jindal SK, , Jha LK, , Gupta D. Bronchial hyper-responsiveness of women with asthma exposed to environmental tobacco smoke. Indian J Chest Dis Allied Sci, 41:75\u201382. 1999.","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542163"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.1010"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110288200"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1387OC"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9902025"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8418"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(88)90195-X"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90931-8"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01127.2002"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2106119"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01587.x"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.037473"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200212-1479SO"},{"key":"e_1_3_2_179_2","first-page":"L84","article-title":"Hydrogen peroxide production by alveolar type II cells, alveolar macrophages, and endothelial cells","volume":"261","author":"Kinnula VL","year":"1991","unstructured":"Kinnula VL, , Everitt JI, , Whorton AR, , Crapo JD. Hydrogen peroxide production by alveolar type II cells, alveolar macrophages, and endothelial cells. Am J Physiol, 261:L84\u201391. 1991.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.2.157"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.005611"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.20.13908"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.12.1481"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-3-480"},{"key":"e_1_3_2_185_2","first-page":"170","article-title":"Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes","volume":"12","author":"Klebanoff SJ","year":"1972","unstructured":"Klebanoff SJ, , Hamon CB. Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes. J Reticuloendothel Soc, 12:170\u2013196. 1972.","journal-title":"J Reticuloendothel Soc"},{"key":"e_1_3_2_186_2","volume-title":"The Neutrophil: Function and Clinical Disorders","author":"Klebanoff SJCRA","year":"1978","unstructured":"Klebanoff SJCRA. The Neutrophil: Function and Clinical Disorders. Amsterdam: Elsevier\/North Holland Biomedical Press, 1978."},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807001200"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.4.371"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00361.2007"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/8.5.493"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236989"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01306015"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118962"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9711059"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9904091"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00151.2004"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.014894"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.2.L350"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00033702"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1105"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1156"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1952"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.6.594"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.08.105"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.5.7952544"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.9607066"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-376"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.06.003"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00468-X"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000188210.72062.10"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200701-031AW"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0495-370"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38819-2"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11853"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi971894b"},{"key":"e_1_3_2_216_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760100300281"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1202"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.9.5763"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470110171.ch14"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90360-6"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5730-8_1"},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22201"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.2.351"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.04.006"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1523OC"},{"key":"e_1_3_2_226_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.3010"},{"key":"e_1_3_2_227_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83599-2"},{"key":"e_1_3_2_228_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.05.070185.001543"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"e_1_3_2_230_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071535"},{"key":"e_1_3_2_231_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.003431"},{"key":"e_1_3_2_232_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1567"},{"key":"e_1_3_2_233_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.14.1742"},{"key":"e_1_3_2_234_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)05403-6"},{"key":"e_1_3_2_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(78)90003-0"},{"key":"e_1_3_2_236_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00288.2007"},{"key":"e_1_3_2_237_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02034.x"},{"key":"e_1_3_2_238_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.06.054"},{"key":"e_1_3_2_239_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117118"},{"key":"e_1_3_2_240_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddstr.2006.08.001"},{"key":"e_1_3_2_241_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9809140"},{"key":"e_1_3_2_242_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.010"},{"key":"e_1_3_2_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01084-5"},{"key":"e_1_3_2_244_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.11.639"},{"key":"e_1_3_2_245_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(00)00003-0"},{"key":"e_1_3_2_246_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041624998"},{"key":"e_1_3_2_247_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.351"},{"key":"e_1_3_2_248_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.60"},{"key":"e_1_3_2_249_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437889100"},{"key":"e_1_3_2_250_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00307.x"},{"key":"e_1_3_2_251_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00724-9"},{"key":"e_1_3_2_252_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90375-M"},{"key":"e_1_3_2_253_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1987.135.4.800"},{"key":"e_1_3_2_254_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F273"},{"key":"e_1_3_2_255_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2090781"},{"key":"e_1_3_2_256_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.5.1143.1143"},{"key":"e_1_3_2_257_2","first-page":"889","article-title":"Immunocytochemical localization of extracellular superoxide dismutase in human lung","volume":"70","author":"Oury TD","year":"1994","unstructured":"Oury TD, , Chang LY, , Marklund SL, , Day BJ, , Crapo JD. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest, 70:889\u2013898. 1994.","journal-title":"Lab Invest"},{"key":"e_1_3_2_258_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02222-8"},{"key":"e_1_3_2_259_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00011.2002"},{"key":"e_1_3_2_260_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2206012"},{"key":"e_1_3_2_261_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.07.011"},{"key":"e_1_3_2_262_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70277-X"},{"key":"e_1_3_2_263_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.04.009"},{"key":"e_1_3_2_264_2","doi-asserted-by":"publisher","DOI":"10.1136\/oem.53.1.41"},{"key":"e_1_3_2_265_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90935-0"},{"key":"e_1_3_2_266_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3071"},{"key":"e_1_3_2_267_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.2.2836"},{"key":"e_1_3_2_268_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5549"},{"key":"e_1_3_2_269_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10925"},{"key":"e_1_3_2_270_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.1.57"},{"key":"e_1_3_2_271_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.14.9573"},{"key":"e_1_3_2_272_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)35745-4"},{"key":"e_1_3_2_273_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(87)90105-7"},{"key":"e_1_3_2_274_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108228"},{"key":"e_1_3_2_275_2","first-page":"291","article-title":"Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: Antioxidant therapeutic targets","volume":"1","author":"Rahman I","year":"2002","unstructured":"Rahman I. Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: Antioxidant therapeutic targets. Current Drug Targets, 1:291\u2013315. 2002.","journal-title":"Current Drug Targets"},{"key":"e_1_3_2_276_2","first-page":"95","article-title":"Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases","volume":"36","author":"Rahman I","year":"2003","unstructured":"Rahman I. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J Biochem Mol Biol, 36:95\u2013109. 2003.","journal-title":"J Biochem Mol Biol"},{"key":"e_1_3_2_277_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00053805"},{"key":"e_1_3_2_278_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.8.5088"},{"key":"e_1_3_2_279_2","first-page":"L80","article-title":"Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells","volume":"275","author":"Rahman I","year":"1998","unstructured":"Rahman I, , Bel A, , Mulier B, , Donaldson K, , MacNee W. Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells. Am J Physiol, 275:L80\u201386. 1998.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_280_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.087"},{"key":"e_1_3_2_281_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.016003534.x"},{"key":"e_1_3_2_282_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)01027-7"},{"key":"e_1_3_2_283_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.3.189"},{"key":"e_1_3_2_284_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-43"},{"key":"e_1_3_2_285_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8511586"},{"key":"e_1_3_2_286_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.4767"},{"key":"e_1_3_2_287_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.01.006"},{"key":"e_1_3_2_288_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0259RC"},{"key":"e_1_3_2_289_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb21793.x"},{"key":"e_1_3_2_290_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.1993.1057"},{"key":"e_1_3_2_291_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.6.2419"},{"key":"e_1_3_2_292_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0640649"},{"key":"e_1_3_2_293_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-055OC"},{"key":"e_1_3_2_294_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84781-6"},{"key":"e_1_3_2_295_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.11.929"},{"key":"e_1_3_2_296_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.12.902"},{"key":"e_1_3_2_297_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703841"},{"key":"e_1_3_2_298_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2909::AID-ART479>3.0.CO;2-#"},{"key":"e_1_3_2_299_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5438.304"},{"key":"e_1_3_2_300_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.21.2.f158"},{"key":"e_1_3_2_301_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.6.7767513"},{"key":"e_1_3_2_302_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32289-5"},{"key":"e_1_3_2_303_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00480-4"},{"key":"e_1_3_2_304_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(95)00003-J"},{"key":"e_1_3_2_305_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02011-Z"},{"key":"e_1_3_2_306_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.11.3710"},{"key":"e_1_3_2_307_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.7.8635688"},{"key":"e_1_3_2_308_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.019"},{"key":"e_1_3_2_309_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9707159"},{"key":"e_1_3_2_310_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.6.C1640"},{"key":"e_1_3_2_311_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.12912"},{"key":"e_1_3_2_312_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10030699"},{"key":"e_1_3_2_313_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1461"},{"key":"e_1_3_2_314_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00550-3"},{"key":"e_1_3_2_315_2","first-page":"1750","article-title":"Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma","volume":"7","author":"Soini Y","year":"2001","unstructured":"Soini Y, , Kahlos K, , Napankangas U, , Kaarteenaho-Wiik R, , Saily M, , Koistinen P, , Paaakko P, , Holmgren A, , Kinnula VL. Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. Clin Cancer Res, 7:1750\u20131757. 2001.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_2_316_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic0004986"},{"key":"e_1_3_2_317_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210434200"},{"key":"e_1_3_2_318_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00206-8"},{"key":"e_1_3_2_319_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100011200"},{"key":"e_1_3_2_320_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2748S"},{"key":"e_1_3_2_321_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(99)00016-X"},{"key":"e_1_3_2_322_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.339"},{"key":"e_1_3_2_323_2","first-page":"287","article-title":"Mammalian nitric oxide synthases","volume":"65","author":"Stuehr DJ","year":"1992","unstructured":"Stuehr DJ, , Griffith OW. Mammalian nitric oxide synthases. Adv Enzymol Relat Areas Mol Biol, 65:287\u2013346. 1992.","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"e_1_3_2_324_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.3.433"},{"key":"e_1_3_2_325_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200303000-00004"},{"key":"e_1_3_2_326_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2004.00657.x"},{"key":"e_1_3_2_327_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770909309056758"},{"key":"e_1_3_2_328_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1757"},{"key":"e_1_3_2_329_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1261"},{"key":"e_1_3_2_330_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00805.x"},{"key":"e_1_3_2_331_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm267"},{"key":"e_1_3_2_332_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118796"},{"key":"e_1_3_2_333_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121460"},{"key":"e_1_3_2_334_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07010173"},{"key":"e_1_3_2_335_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770380025"},{"key":"e_1_3_2_336_2","unstructured":"USEPA. Air Quality Criteria for Ozone and Related Photochemical Oxidants (Final) US Environmental Protection Agency: Washington DCEPA\/600\/R\u201305\/004aF-cF.2006."},{"key":"e_1_3_2_337_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90078-9"},{"key":"e_1_3_2_338_2","doi-asserted-by":"publisher","DOI":"10.1086\/503809"},{"key":"e_1_3_2_339_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.01507.x"},{"key":"e_1_3_2_340_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00399-X"},{"key":"e_1_3_2_341_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.826.536"},{"key":"e_1_3_2_342_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3018933"},{"key":"e_1_3_2_343_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb21812.x"},{"key":"e_1_3_2_344_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx00040a007"},{"key":"e_1_3_2_345_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(89)90058-7"},{"key":"e_1_3_2_346_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3263703"},{"key":"e_1_3_2_347_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1010OC"},{"key":"e_1_3_2_348_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9702"},{"key":"e_1_3_2_349_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00441.2002"},{"key":"e_1_3_2_350_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2317fje"},{"key":"e_1_3_2_351_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(03)00006-3"},{"key":"e_1_3_2_352_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.23.14085"},{"key":"e_1_3_2_353_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.01.005"},{"key":"e_1_3_2_354_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116959"},{"key":"e_1_3_2_355_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)90023-X"},{"key":"e_1_3_2_356_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14038"},{"key":"e_1_3_2_357_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)46227-2"},{"key":"e_1_3_2_358_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421109"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2008.2425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2008.2425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2008.2425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:50:13Z","timestamp":1777377013000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2008.2425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":357,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1089\/ars.2008.2425"],"URL":"https:\/\/doi.org\/10.1089\/ars.2008.2425","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}