{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:23:04Z","timestamp":1777432984114,"version":"3.51.4"},"reference-count":78,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>\n                    Vertebrate cardiorespiratory homeostasis is inextricably dependent upon specialized cells that provide feedback on oxygen status in the tissues, blood, and on occasion, environment. These \u201coxygen sensing\u201d cells include chemoreceptors and oxygen-sensitive chromaffin cells that initiate cardiorespiratory reflexes, vascular smooth muscle cells that adjust perfusion to metabolism or ventilation, and other cells that condition themselves in response to episodic hypoxia. Identification of how these cells sense oxygen and transduce this into the appropriate physiological response has enormous clinical applicability, but despite intense research there is no consensus regarding the initial hypoxia-effector coupling mechanism. This review examines an alternative mechanism of oxygen sensing using oxidation of endogenously produced hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) as the O\n                    <jats:sub>2<\/jats:sub>\n                    -sensitive couple. Support for this hypothesis includes the similarity of effects of hypoxia and H\n                    <jats:sub>2<\/jats:sub>\n                    S on a variety of tissues, augmentation of hypoxic responses by precursors of H\n                    <jats:sub>2<\/jats:sub>\n                    S production and their inhibition by inhibitors of H\n                    <jats:sub>2<\/jats:sub>\n                    S synthesis, and the rapid consumption of H\n                    <jats:sub>2<\/jats:sub>\n                    S by O\n                    <jats:sub>2<\/jats:sub>\n                    in the range of intracellular\/mitochondrial P\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    . These studies also indicate that, under normoxic conditions, it is doubtful that free H\n                    <jats:sub>2<\/jats:sub>\n                    S has longer than a transient existence in tissue or extracellular fluid.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    12, 1219\u20131234.\n                  <\/jats:p>","DOI":"10.1089\/ars.2009.2921","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T13:44:53Z","timestamp":1254750293000},"page":"1219-1234","source":"Crossref","is-referenced-by-count":122,"title":["Hydrogen Sulfide and Oxygen Sensing in the Cardiovascular System"],"prefix":"10.1177","volume":"12","author":[{"given":"Kenneth R.","family":"Olson","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan L.","family":"Whitfield","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine"},{"name":"University of Notre Dame"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706906"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787846631"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(92)90015-F"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.092023"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018199"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00978.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00853.2007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2005.03.024"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02376"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705891104"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.033514"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icm080"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90566.2008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.094"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.130"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.06.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06482.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0346-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0321-4"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108019"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)21916-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00248.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.069294"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00122-8"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2206009"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.08.006"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01193.2006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.12.023"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1130\/G21295.1"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.05.063"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00195.2008"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00929.2003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-806-9_16"},{"key":"e_1_3_2_36_2","first-page":"A252","article-title":"Precursors of hydrogen sulfide synthesis augment acute hypoxic pulmonary vasoconstriction in the intact lung","volume":"177","author":"Madden JA","year":"2008","unstructured":"Madden JA, , Olson KR, , Roerig DL. 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