{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:32:34Z","timestamp":1777433554757,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    Nitroxyl (HNO) displays distinct pharmacology to its redox congener nitric oxide (NO\n                    <jats:sup>\u2022<\/jats:sup>\n                    ) with therapeutic potential in the treatment of heart failure. It remains unknown if HNO donors are resistant to tolerance development following chronic\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    administration. Wistar\u2013Kyoto rats received a 3-day subcutaneous infusion of one of the NO\n                    <jats:sup>\u2022<\/jats:sup>\n                    donors, glyceryl trinitrate (GTN) or diethylamine\/NONOate (DEA\/NO), or the HNO donor Angeli's salt (AS). GTN infusion (10\u2009\u03bcg\/kg\/min) resulted in significantly blunted depressor responses to intravenous bolus doses of GTN, demonstrating tolerance development. By contrast, infusion with AS (20\u2009\u03bcg\/kg\/min) or DEA\/NO (2\u2009\u03bcg\/kg\/min) did not alter their subsequent depressor responses. Similarly,\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    vasorelaxation responses in isolated aortae revealed that GTN infusion elicited a significant 6-fold decrease in the sensitivity to GTN and reduction in the maximum response to acetylcholine (ACh). Chronic infusion of AS or DEA\/NO had no effect on subsequent vasorelaxation responses to themselves or to ACh. No functional cross-tolerance between nitrovasodilators was evident, either\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    , although an impaired ability of a nitrovasodilator to increase tissue cGMP content was not necessarily indicative of a reduced functional response. In conclusion, HNO donors may represent novel therapies for cardiovascular disease with therapeutic potential over clinically used organic nitrates.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    14, 1615\u20131624.\n                  <\/jats:p>","DOI":"10.1089\/ars.2010.3269","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T00:15:57Z","timestamp":1284941757000},"page":"1615-1624","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Chronic Administration of the HNO Donor Angeli's Salt Does Not Lead to Tolerance, Cross-Tolerance, or Endothelial Dysfunction: Comparison with GTN and DEA\/NO"],"prefix":"10.1177","volume":"14","author":[{"given":"Jennifer C.","family":"Irvine","sequence":"first","affiliation":[{"name":"Monash University","place":["Australia"]},{"name":"Baker IDI Heart and Diabetes Institute","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara K.","family":"Kemp-Harper","sequence":"additional","affiliation":[{"name":"Monash University","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Widdop","sequence":"additional","affiliation":[{"name":"Monash University","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00150.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-01-0062"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503723102"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122225199"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129254"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0588-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01289-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00080-X"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(96)00142-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)37672-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703058"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.11.018"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00008.2009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)10384-4"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01510-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000072010.54901.DE"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000259328.04159.90"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.08.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4401.098432"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041354"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.188441"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00027-2"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14617"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.094763"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27657"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm050151i"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(02)00498-1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1430507100"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00031-0"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.020909"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.17.2188"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702622"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.1.e7"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000184694.03262.6d"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01179-6"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.11.002"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937302100"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181191198"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704127"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.08.001"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419267"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000253904.53601.c9"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)00015-X"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704532"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704269"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.143909"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS103S124S"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1668"}],"container-title":["Antioxidants 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