{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:48:49Z","timestamp":1790617729886,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    Nitric oxide-mediated vasodilatation has previously been attributed to the uncharged form of the molecule (NO\n                    <jats:sup>\u2022<\/jats:sup>\n                    ), but increasing evidence suggests that nitroxyl (HNO) may play a significant role in endothelium-dependent relaxation. The aim of this study was to investigate the mechanisms underlying HNO-mediated vasodilatation in phenylephrine pre-constricted pressurized (70\u2009mmHg) mesenteric arteries, and on membrane currents in isolated smooth muscle cells using whole cell and perforated patch clamp recordings. Angeli's salt (AS: nitroxyl donor), evoked concentration-dependent vasodilatation that was insensitive to the NO\n                    <jats:sup>\u2022<\/jats:sup>\n                    scavengers carboxy-PTIO and hydroxocobalamin (HXC), but sensitive to either the HNO scavenger L-cysteine, K-channel blockers (4-AP and iberiotoxin), raised [K\n                    <jats:sup>+<\/jats:sup>\n                    ]\n                    <jats:sub>o<\/jats:sub>\n                    , or inhibition of soluble guanylyl cyclase (ODQ). AS-evoked smooth muscle hyperpolarization significantly augmented K\n                    <jats:sub>V<\/jats:sub>\n                    current in an ODQ sensitive manner, and also increased the BK\n                    <jats:sub>Ca<\/jats:sub>\n                    current. Importantly, 30\u2009\u03bc\n                    <jats:italic toggle=\"yes\">M<\/jats:italic>\n                    AS initiated conducted or spreading vasodilatation, and following blockade of endothelial K-channels (TRAM-34 and apamin), ACh was able to evoke similar L-cysteine-sensitive conducted dilatation. These data show that vasodilatation induced by HNO is mediated by both K\n                    <jats:sub>V<\/jats:sub>\n                    and BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channels, and suggest a physiological role in vasodilatation through the vasculature.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    14, 1625\u20131635.\n                  <\/jats:p>","DOI":"10.1089\/ars.2010.3279","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T11:08:46Z","timestamp":1278587326000},"page":"1625-1635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["A Novel Role for HNO in Local and Spreading Vasodilatation in Rat Mesenteric Resistance Arteries"],"prefix":"10.1177","volume":"14","author":[{"given":"Kathryn H.","family":"Yuill","sequence":"first","affiliation":[{"name":"Department of Pharmacology","place":["United Kingdom"]},{"name":"University of Bath","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Yarova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["United Kingdom"]},{"name":"University of Bath","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara K.","family":"Kemp-Harper","sequence":"additional","affiliation":[{"name":"Monash University","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Garland","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Dora","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004337200"},{"issue":"2","key":"e_1_3_3_3_2","first-page":"S1","article-title":"Guide to Receptors and Channels (GRAC), 3rd edition","volume":"153","author":"Alexander SP","year":"2008","unstructured":"Alexander SP, , Mathie A, , Peters JA. Guide to Receptors and Channels (GRAC), 3rd edition. 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Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators. 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