{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:42:48Z","timestamp":1787730168514,"version":"build-2784847793"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>\n                    We previously reported a spontaneous development of type 2 diabetes\u2013like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficiency eliminated these two primary effects of GPX1 overproduction. Forty-seven male OE and wild-type (WT) mice were fed an Se-adequate (0.4\u2009mg Se\/kg) or deficient (&lt;0.02\u2009mg Se\/kg) diet at 2 to 3\u2009g (full-fed\u2009=\u20095\u2009g) per day from 4 to 12 weeks of age. Although dietary Se deficiency did not rescue the primary phenotypes of the diet-restricted OE mice, it exerted a strong effect (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) on mRNA or protein levels (or both) of 14 molecules involved in islet insulin synthesis and secretion and hepatic lipogenesis. Dietary Se deficiency exhibited a hypoinsulinemic trend in OE mice and a strong hypolipidemic effect (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in the liver of WT mice. Hepatic lipogenesis was attenuated in OE compared with WT mice. In conclusion, diet restriction might be too overwhelming to allow a demonstration of a dietary Se-depletion effect on the OE phenotypes. Full-fed animals could offer a better chance to illustrate such effects and the underlying mechanisms.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    14, 383\u2013390.\n                  <\/jats:p>","DOI":"10.1089\/ars.2010.3295","type":"journal-article","created":{"date-parts":[[2010,6,27]],"date-time":"2010-06-27T19:22:47Z","timestamp":1277666567000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Impacts of Dietary Selenium Deficiency on Metabolic Phenotypes of Diet-Restricted GPX1-Overexpressing Mice"],"prefix":"10.1177","volume":"14","author":[{"given":"Matthew P.","family":"Pepper","sequence":"first","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko Z.","family":"Vatamaniuk","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yan","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Roneker","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Gen","family":"Lei","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520140117"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006819227506"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05971"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-4-200708210-00177"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1726"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn414"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.416"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.9.2040"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030544"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.675"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.7.1070"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.2.395"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-998-0220-z"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)40166-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.17.1.325"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.12.022"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1990393"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.9.2455"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.068"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0708"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04634"},{"key":"e_1_3_3_23_2","first-page":"1589","article-title":"Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: studies in GH-deficient patients and healthy untreated subjects","volume":"77","author":"Jorgensen JO","year":"1993","unstructured":"Jorgensen JO, , Moller J, , Alberti KG, , Schmitz O, , Christiansen JS, , Orskov H, , Moller N. Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: studies in GH-deficient patients and healthy untreated subjects. J Clin Endocrinol Metab, 77:1589\u20131596. 1993.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.12.2398"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K07E-041"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083516"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.6.1939"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.831552"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.01.005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180306597"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)02051-5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664250"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.864"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0129"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308096101"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2109"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-6-23"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.12.005"},{"key":"e_1_3_3_39_2","volume-title":"Exercise Physiology","author":"Powers S","year":"2001","unstructured":"Powers S, , Howley E. Exercise Physiology. Boston: McGraw Hill, 2001."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.04.030"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1984.247.2.E157"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118951"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.111252"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-4-200708210-00175"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20080146"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192445199"},{"key":"e_1_3_3_47_2","first-page":"347","article-title":"Selenium-induced growth retardation: histochemical and endocrinological studies on the anterior pituitaries of selenium treated rats","volume":"37","author":"Thorlacius-Ussing O","year":"1990","unstructured":"Thorlacius-Ussing O. Selenium-induced growth retardation: histochemical and endocrinological studies on the anterior pituitaries of selenium treated rats. Dan Med Bull, 37:347\u2013358. 1990.","journal-title":"Dan Med Bull"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26367"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90234-8"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1055-3"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00378-6"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2010.3295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2010.3295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2010.3295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:51:18Z","timestamp":1777377078000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2010.3295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1089\/ars.2010.3295"],"URL":"https:\/\/doi.org\/10.1089\/ars.2010.3295","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}