{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:34:08Z","timestamp":1790861648208,"version":"4.1.0"},"reference-count":80,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    The discovery of human DNA polymerase eta (pol \u03b7) has a major impact on the fields of DNA replication\/repair fields. Since the discovery of human pol \u03b7, a number of new DNA polymerases with the ability to bypass various DNA lesions have been discovered. Among these polymerases, pol \u03b7 is the most extensively studied lesion bypass polymerase with a defined major biological function, that is, to replicate across the cyclobutane pyrimidine dimers introduced by UV irradiation. Cyclobutane pyrimidine dimer is a major DNA lesion that causes distortion of DNA structure and block the replicative DNA polymerases during DNA replication process. Genetic defects in the pol \u03b7 gene,\n                    <jats:italic toggle=\"yes\">Rad30<\/jats:italic>\n                    , results in a disease called xeroderma pigmentosum variant. This review focuses on the overall properties of pol \u03b7 and the mechanism that involved in regulating its activity in cells. In addition, the role of pol \u03b7 in the action of DNA-targeting anticancer compounds is also discussed.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    14, 2521\u20132529.\n                  <\/jats:p>","DOI":"10.1089\/ars.2010.3673","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T05:34:49Z","timestamp":1288935289000},"page":"2521-2529","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["DNA Polymerase Eta and Chemotherapeutic Agents"],"prefix":"10.1177","volume":"14","author":[{"given":"Kai-ming","family":"Chou","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01196-07"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809844105"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005492107"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148242"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.03.022"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.7.811"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1328"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi035359p"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2003.08.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120615"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.12.039"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09196"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601123"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1995.0012"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050300"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100056200"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/6.suppl_3.S57"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0310252"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1227"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2004.08.008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(99)00149-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0118"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808589105"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.neo.7900122"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00324a025"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505236200"},{"key":"e_1_3_2_28_2","first-page":"4453","article-title":"Excision of 2',2'-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA","volume":"56","author":"Gandhi V","year":"1996","unstructured":"Gandhi V, , Legha J, , Chen F, , Hertel LW, , Plunkett W. 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