{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:34:55Z","timestamp":1777433695351,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>\n                    Diabetes exacerbates ischemic heart disease morbidity and mortality\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    incompletely understood mechanisms. Although adiponectin (APN) reduces myocardial ischemia\/reperfusion (MI\/R) injury in nondiabetic animals, whether APN's cardioprotective actions are altered in diabetes, a pathologic condition with endogenously reduced APN, has never been investigated. High-fat diet (HD)\u2013induced diabetic mice and normal diet (ND) controls were subjected to MI\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    coronary artery ligation, and given vehicle or APN globular domain (gAPN, 2\u2009\u03bcg\/g) 10\u2009min before reperfusion. Compared to ND mice (where gAPN exerted pronounced cardioprotection), HD mice manifested greater MI\/R injury, and a tripled gAPN dose was requisite to achieve cardioprotective extent seen in ND mice (\n                    <jats:italic toggle=\"yes\">i.e<\/jats:italic>\n                    ., infarct size, apoptosis, and cardiac function). APN reduces MI\/R injury\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    AMP-activated protein kinase (AMPK)\u2013dependent metabolic regulation and AMPK-independent antioxidative\/antinitrative pathways. Compared to ND, HD mice manifested significantly blunted gAPN-induced AMPK activation, basally and after MI\/R (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Although both low- and high-dose gAPN equally attenuated MI\/R-induced oxidative stress (\n                    <jats:italic toggle=\"yes\">i.e<\/jats:italic>\n                    ., NADPH oxidase expression and superoxide production) and nitrative stress (\n                    <jats:italic toggle=\"yes\">i.e<\/jats:italic>\n                    ., inducible nitric oxide synthase expression, nitric oxide production, and peroxynitrite formation) in ND mice, only high-dose gAPN efficaciously did so in HD mice. We demonstrate for the first time that HD-induced diabetes diminished both AMPK-dependent and AMPK-independent APN cardioprotection, suggesting an unreported diabetic heart APN resistance.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    15, 1779\u20131788.\n                  <\/jats:p>","DOI":"10.1089\/ars.2010.3722","type":"journal-article","created":{"date-parts":[[2010,11,21]],"date-time":"2010-11-21T10:31:05Z","timestamp":1290335465000},"page":"1779-1788","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Reduced Cardioprotective Action of Adiponectin in High-Fat Diet\u2013Induced Type II Diabetic Mice and Its Underlying Mechanisms"],"prefix":"10.1177","volume":"15","author":[{"given":"Wei","family":"Yi","sequence":"first","affiliation":[{"name":"Thomas Jefferson University"},{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"},{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhe","family":"Gao","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xufeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"},{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne Bond","family":"Lau","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"},{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Wang","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Tao","sequence":"additional","affiliation":[{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Koch","sequence":"additional","affiliation":[{"name":"Fourth Military Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0185"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1111"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/90992"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.11.3154"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307878200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1980"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705891104"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1067"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-007-0006-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1398"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1595"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29126"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.3.253"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000048856.22331.50"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.03.002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90774.2008"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00545.2006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2006.03.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.14.1730"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.07.022"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.02.057"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402558200"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1295"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666941"},{"issue":"1","key":"e_1_3_3_27_2","first-page":"S18","article-title":"Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus","volume":"25","author":"Venables MC","year":"2009","unstructured":"Venables MC, , Jeukendrup AE. 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