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It is becoming increasingly clear that many of the biological actions of HNO can be attributed to its ability to react with specific thiol- and, possibly, heme-proteins. Herein is discussed the chemistry of HNO with likely biological targets. A particular focus is given to targets associated with the pharmacological utility of HNO as a cardiovascular agent and for the treatment of alcoholism.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    14, 1649\u20131657.\n                  <\/jats:p>","DOI":"10.1089\/ars.2010.3855","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T20:13:39Z","timestamp":1295036019000},"page":"1649-1657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["HNO Signaling Mechanisms"],"prefix":"10.1177","volume":"14","author":[{"given":"Jon M.","family":"Fukuto","sequence":"first","affiliation":[{"name":"Sonoma State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Carrington","sequence":"additional","affiliation":[{"name":"Sonoma State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00150.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00756-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja036370f"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041481598"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162095599"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-01-0062"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/02603598808072309"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703812"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.07.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.15.8262333"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00509.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(78)90121-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(83)90063-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129254"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(85)90027-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00080-X"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(96)00142-5"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00078-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.471714"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00210a047"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2004.11.005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1031571100"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi801925p"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)10384-4"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx0496800"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.06.014"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2597"},{"key":"e_1_3_2_29_2","first-page":"1003","article-title":"A pulse radiolytic study of short-lived byproducts on nitric oxide reduction in aqueous solution","volume":"74","author":"Gratzel M","year":"1970","unstructured":"Gratzel M, , Taniguchi S, , Henglein A. 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