{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:05:27Z","timestamp":1790399127623,"version":"4.1.0"},"reference-count":60,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    On the one hand, redox emerges as a key mechanism in regulating intra- and intercellular signaling and homeostatic systems. On the other hand, cells of the B lineage provide powerful systems to unravel the intra- and intercellular mechanisms that coordinate the processes of development and terminal differentiation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    This essay summarizes a few paradigmatic examples of redox regulation and signal modulation that emerged from, or were confirmed by, studies on the development, differentiation and function of B cells.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    While a role for intra- and intercellular redox signaling has been firmly established for differentiating B cells, many fundamental questions remain open, including the cellular sources of reactive oxygen species (ROS), the spatial and temporal constraints of ROS signaling, and the functional role of the antioxidant response.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    Given their robustness and biotechnological and clinical interest, cells of the B lineage continue to be fruitful goldmines from which redox biologists can dig novel mechanistic knowledge of general relevance.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    16, 1139\u20131149.\n                  <\/jats:p>","DOI":"10.1089\/ars.2011.4252","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T17:22:42Z","timestamp":1326129762000},"page":"1139-1149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["On the Redox Control of B Lymphocyte Differentiation and Function"],"prefix":"10.1177","volume":"16","author":[{"given":"Milena","family":"Bertolotti","sequence":"first","affiliation":[{"name":"Universit\u00e0 Vita-Salute San Raffaele Scientific Institute","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sitia","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Vita-Salute San Raffaele Scientific 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