{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:13:00Z","timestamp":1791400380211,"version":"4.3.3"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aim:<\/jats:italic>\n                    <\/jats:bold>\n                    It has been convincingly shown that oxidative stress and toxicity by deregulated metals, such as copper (Cu), are tightly linked to the development of pre-eclampsia and intrauterine growth retardation (IUGR), the most threatening pathologies of human pregnancy. However, mechanisms implemented to control these effects are far from being understood. Among proteins that bind Cu and insure cellular protection against oxidative stress is the cellular prion protein (PrP\n                    <jats:sup>C<\/jats:sup>\n                    ), a glycosyl phosphatidyl inositol-anchored glycoprotein, which we reported to be highly expressed in human placenta. Herein, we investigated the pathophysiological role of PrP\n                    <jats:sup>C<\/jats:sup>\n                    in Cu and oxidative stress homeostasis\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    using human placenta and trophoblast cells, and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    using three strains of mice (C57Bl6, PrP\n                    <jats:sup>C<\/jats:sup>\n                    knockout mice [PrP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ], and PrP\n                    <jats:sup>C<\/jats:sup>\n                    overexpressing mice [Tga20]).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    At the cellular level, PrP\n                    <jats:sup>C<\/jats:sup>\n                    protection against oxidative stress was established in multiple angiogenic processes: proliferation, migration, and tube-like organization. For the animal models, lack (PrP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) or overexpression (Tga20) of PrP\n                    <jats:sup>C<\/jats:sup>\n                    in gravid mice caused severe IUGR that was correlated with a decrease in litter size, changes in Cu homeostasis, increase in oxidative stress response, development of hypoxic environment, failure in placental function, and maintenance of growth defects of the offspring even 7.5 months after delivery.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation:<\/jats:italic>\n                    <\/jats:bold>\n                    PrP\n                    <jats:sup>C<\/jats:sup>\n                    could serve as a marker for the idiopathic IUGR disease.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    These findings demonstrate the stress-protective role of PrP\n                    <jats:sup>C<\/jats:sup>\n                    during development, and propose PrP\n                    <jats:sup>C<\/jats:sup>\n                    dysregulation as a novel causative element of IUGR.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                    . 18, 400\u2013411.\n                  <\/jats:p>","DOI":"10.1089\/ars.2012.4637","type":"journal-article","created":{"date-parts":[[2012,8,4]],"date-time":"2012-08-04T14:35:30Z","timestamp":1344090930000},"page":"400-411","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Prion Protein Expression and Functional Importance in Developmental Angiogenesis: Role in Oxidative Stress and Copper Homeostasis"],"prefix":"10.1177","volume":"18","author":[{"given":"Nadia","family":"Alfaidy","sequence":"first","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique (CEA)","place":["France"]},{"name":"Universit\u00e9 Joseph Fourrier (UJF)","place":["France"]},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Chauvet","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique (CEA)","place":["France"]},{"name":"Universit\u00e9 Joseph Fourrier (UJF)","place":["France"]},{"name":"Centre National de la Recherche Scientifique (CNRS)","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Donadio-Andrei","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique (CEA)","place":["France"]},{"name":"Universit\u00e9 Joseph Fourrier (UJF)","place":["France"]},{"name":"Centre National de la Recherche Scientifique (CNRS)","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Salomon","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique (CEA)","place":["France"]},{"name":"Universit\u00e9 Joseph Fourrier 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