{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:37:20Z","timestamp":1790361440102,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    <\/jats:bold>\n                    Fibromyalgia (FM) is a prevalent chronic pain syndrome characterized by generalized hyperalgesia associated with a wide spectrum of symptoms such as fatigue and joint stiffness. Diagnosis of FM is difficult due to the lack of reliable diagnostic biomarkers, while treatment is largely inadequate. We have investigated the role of coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    (CoQ\n                    <jats:sub>10<\/jats:sub>\n                    ) deficiency and mitochondrial dysfunction in inflammasome activation in blood cells from FM patients, and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    CoQ\n                    <jats:sub>10<\/jats:sub>\n                    deficiency models.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Mitochondrial dysfunction was accompanied by increased protein expression of interleukin (IL)-1\u03b2, NLRP3 (NOD-like receptor family, pyrin domain containing 3) and caspase-1 activation, and an increase of serum levels of proinflammatory cytokines (IL-1\u03b2 and IL-18). CoQ\n                    <jats:sub>10<\/jats:sub>\n                    deficiency induced by p-aminobenzoate treatment in blood mononuclear cells and mice showed NLRP3 inflammasome activation with marked algesia. A placebo-controlled trial of CoQ\n                    <jats:sub>10<\/jats:sub>\n                    in FM patients has shown a reduced NLRP3 inflammasome activation and IL-1\u03b2 and IL-18 serum levels.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation:<\/jats:italic>\n                    <\/jats:bold>\n                    These results show an important role for the NLRP3 inflammasome in the pathogenesis of FM, and the capacity of CoQ10 in the control of inflammasome.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    These findings provide new insights into the pathogenesis of FM and suggest that NLRP3 inflammasome inhibition represents a new therapeutic intervention for the disease.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    20, 1169\u20131180.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5198","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T12:09:24Z","timestamp":1374754164000},"page":"1169-1180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":95,"title":["NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q\n                    <sub>10<\/sub>"],"prefix":"10.1177","volume":"20","author":[{"given":"Mario D.","family":"Cordero","sequence":"first","affiliation":[{"name":"Universidad de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edsabet","family":"Alcocer-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Universidad de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognjen","family":"Culic","sequence":"additional","affiliation":[{"name":"University of Zagreb","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel M.","family":"Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Universidad Pablo de Olavide de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"de Miguel","sequence":"additional","affiliation":[{"name":"Universidad de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"D\u00edaz-Parrado","sequence":"additional","affiliation":[{"name":"Universidad de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"P\u00e9rez-Villegas","sequence":"additional","affiliation":[{"name":"Universidad Pablo de Olavide de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Bull\u00f3n","sequence":"additional","affiliation":[{"name":"Universidad de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"S\u00e1nchez-Alcazar","sequence":"additional","affiliation":[{"name":"Universidad Pablo de Olavide-CSIC-Junta de Andaluc\u00eda and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER)","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100006X116628"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0427-8"},{"key":"e_1_3_3_4_2","first-page":"137","article-title":"Coenzyme Q can control the efficiency of oxidative phosphorylation","volume":"12","author":"Battino M","year":"1990","unstructured":"Battino M, , Fato R, , Parenti-Castelli G, , and Lenaz G. Coenzyme Q can control the efficiency of oxidative phosphorylation. Int J Tissue React, 12: 137\u2013144, 1990.","journal-title":"Int J Tissue React"},{"key":"e_1_3_3_5_2","first-page":"225","article-title":"Cytokine patterns in fibromyalgia and their correlation with clinical manifestations","volume":"25","author":"Bazzichi L","year":"2007","unstructured":"Bazzichi L, , Rossi A, , Massimetti G, , Giannaccini G, , Giuliano T, , De Feo F, , Ciapparelli A, , Dell'Osso L, , and Bombardieri S. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol, 25: 225\u2013230, 2007.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026915"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.03.122"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2918"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4892"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.12.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008480"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.09.032"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2278fje"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04440.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.03.007"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.106"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0079-y"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.01.003"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-100149"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.1.7174"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874226201003010009"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)90055-8"},{"key":"e_1_3_3_25_2","first-page":"146","article-title":"Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia","volume":"30","author":"Salemi S","year":"2003","unstructured":"Salemi S, , Rethage J, , Wollina U, , Michel BA, , Gay RE, , Gay S, , and Sprott H. Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia. J Rheumatol, 30: 146\u2013150, 2003.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/11530950-000000000-00000"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2003.11.012"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.11.005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161206775193208"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2013.5198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:14Z","timestamp":1777377194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2013.5198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1089\/ars.2013.5198"],"URL":"https:\/\/doi.org\/10.1089\/ars.2013.5198","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}