{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:52:42Z","timestamp":1783947162986,"version":"3.55.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    <\/jats:bold>\n                    Free iron plays an important role in the pathogenesis of acute kidney injury (AKI)\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    the formation of hydroxyl radicals. Systemic iron homeostasis is controlled by the hemojuvelin-hepcidin-ferroportin axis in the liver, but less is known about this role in AKI.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    By proteomics, we identified a 42\u2009kDa soluble hemojuvelin (sHJV), processed by furin protease from membrane-bound hemojuvelin (mHJV), in the urine during AKI after cardiac surgery. Biopsies from human and mouse specimens with AKI confirm that HJV is extensively increased in renal tubules. Iron overload enhanced the expression of hemojuvelin-hepcidin signaling pathway. The furin inhibitor (FI) decreases furin-mediated proteolytic cleavage of mHJV into sHJV and augments the mHJV\/sHJV ratio after iron overload with hypoxia condition. The FI could reduce renal tubule apoptosis, stabilize hypoxic induced factor-1, prevent the accumulation of iron in the kidney, and further ameliorate ischemic-reperfusion injury. mHJV is associated with decreasing total kidney iron, secreting hepcidin, and promoting the degradation of ferroportin at AKI, whereas sHJV does the opposite.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation:<\/jats:italic>\n                    <\/jats:bold>\n                    This study suggests the ratio of mHJV\/sHJV affects the iron deposition during acute kidney injury and sHJV could be an early biomarker of AKI.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Our findings link endogenous HJV inextricably with renal iron homeostasis for the first time, add new significance to early predict AKI, and identify novel therapeutic targets to reduce the severity of AKI using the FI.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                    . 20, 1181\u20131194.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5366","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T14:23:42Z","timestamp":1375280622000},"page":"1181-1194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Hemojuvelin Modulates Iron Stress During Acute Kidney Injury: Improved by Furin Inhibitor"],"prefix":"10.1177","volume":"20","author":[{"given":"Guang-Huar","family":"Young","sequence":"first","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao-Min","family":"Huang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hsiung","family":"Wu","sequence":"additional","affiliation":[{"name":"Buddhist Tzu Chi General Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Fu","family":"Lai","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Cheng","family":"Hou","sequence":"additional","affiliation":[{"name":"Min-Sheng General Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Yung","family":"Peng","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Jung","family":"Liang","sequence":"additional","affiliation":[{"name":"National Taiwan University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuei-Liong","family":"Lin","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chung","family":"Chang","sequence":"additional","affiliation":[{"name":"National Taiwan University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi-Ru","family":"Tsai","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Je","family":"Ko","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital","place":["Taiwan"]},{"name":"National Taiwan University Hospital","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the NSARF group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31342"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2910901"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.53"},{"key":"e_1_3_3_5_2","unstructured":"This reference has been deleted."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.418"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.10.704"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.12.034"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.04.014"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22593"},{"key":"e_1_3_3_11_2","first-page":"4","article-title":"Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression","author":"El-Achkar TM","year":"2008","unstructured":"El-Achkar TM, , Wu XR, , Rauchman M, , McCracken R, , Kiefer S, , and Dagher PC. Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression. Am J Physiol Renal Physiol 295: F53, 4\u2013F544, 2008.","journal-title":"Am J Physiol Renal Physiol 295: F53"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.046"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86093-B"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.2.329"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.10.037"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25049"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050553"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.195"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.6028\/jres.093.041"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500488"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1845"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413248200"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23056"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(03)00181-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25683"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.205"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009357"},{"key":"e_1_3_3_29_2","first-page":"1441","article-title":"Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin","volume":"89","author":"Rodriguez Martinez A","year":"2004","unstructured":"Rodriguez Martinez A, , Niemela O, , and Parkkila S. Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin. Haematologica, 89: 1441\u20131445, 2004.","journal-title":"Haematologica"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.6"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.7136-7139.2002"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.602-605.2004"},{"key":"e_1_3_3_33_2","unstructured":"This reference has been deleted."},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100677"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-041004"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90159-2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05191107"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113325"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809095200"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.04.006"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0813-x"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1135"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.01.007"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9339-8"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506207200"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.027318"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2013.5366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:14Z","timestamp":1777377194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2013.5366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1089\/ars.2013.5366"],"URL":"https:\/\/doi.org\/10.1089\/ars.2013.5366","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}