{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:56:54Z","timestamp":1791327414682,"version":"4.3.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    <\/jats:bold>\n                    Ectopic activation of tissue-specific genes accompanies malignant transformation in many cancers.\n                    <jats:italic toggle=\"yes\">Prolactin<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    ) aberrant activation in lung cancer was investigated here to highlight its value as a biomarker.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    is ectopically activated in a subset of very aggressive lung tumors, associated with a rapid fatal outcome, in our cohort of 293 lung tumor patients and in an external independent series of patients. Surprisingly PRL receptor expression was not detected in the vast majority of\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    -expressing lung tumors. Additionally, the analysis of the\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    transcripts in lung tumors and cell lines revealed systematic truncations of their 5\u2032 regions, including the signal peptide-encoding portions.\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    expression was found to sustain cancer-specific gene expression circuits encompassing genes that are normally responsive to hypoxia. Interestingly, this analysis also indicated that histone deacetylase (HDAC) inhibitors could counteract the\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    -associated transcriptional activity.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation and Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Altogether, this work not only unravels a yet unknown oncogenic mechanism but also indicates that the specific category of\n                    <jats:italic toggle=\"yes\">PRL<\/jats:italic>\n                    -expressing aggressive lung cancers could be particularly responsive to an HDAC inhibitor-based treatment.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    23, 1\u201314.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5581","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T10:07:17Z","timestamp":1392026837000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Receptor-Independent Ectopic Activity of\n                    <i>Prolactin<\/i>\n                    Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies"],"prefix":"10.1177","volume":"23","author":[{"given":"Aurore","family":"Le Bescont","sequence":"first","affiliation":[{"name":"Universit\u00e9 Joseph Fourier\u2013Grenoble 1","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Vitte","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Joseph Fourier\u2013Grenoble 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