{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:16:22Z","timestamp":1791299782836,"version":"4.1.0"},"reference-count":206,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    Hepatic fibrosis is the common pathophysiologic process resulting from chronic liver injury, characterized by the accumulation of an excessive extracellular matrix. Multiple lines of evidence indicate that oxidative stress plays a pivotal role in the pathogenesis of liver fibrosis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. In addition to phagocytic NOX2, there are six nonphagocytic NOX proteins.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    In the liver, NOX is functionally expressed both in the phagocytic form and in the nonphagocytic form. NOX-derived ROS contributes to various kinds of liver disease caused by alcohol, hepatitis C virus, and toxic bile acids. Recent evidence indicates that both phagocytic NOX2 and nonphagocytic NOX isoforms, including NOX1 and NOX4, mediate distinct profibrogenic actions in hepatic stellate cells, the main fibrogenic cell type in the liver. The critical role of NOX in hepatic fibrogenesis provides a rationale to assess pharmacological NOX inhibitors that treat hepatic fibrosis in patients with chronic liver disease.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    Although there is compelling evidence indicating a crucial role for NOX-mediated ROS generation in hepatic fibrogenesis, little is known about the expression, subcellular localization, regulation, and redox signaling of NOX isoforms in specific cell types in the liver. Moreover, the exact mechanism of NOX-mediated fibrogenic signaling is still largely unknown.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    A better understanding through further research about NOX-mediated fibrogenic signaling may enable the development of novel anti-fibrotic therapy using NOX inhibition strategy.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    20, 2854\u20132872.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5619","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T12:23:17Z","timestamp":1379334197000},"page":"2854-2872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":207,"title":["Role of NADPH Oxidases in Liver Fibrosis"],"prefix":"10.1177","volume":"20","author":[{"given":"Yong-Han","family":"Paik","sequence":"first","affiliation":[{"name":"Sungkyunkwan University School of Medicine"},{"name":"Sungkyunkwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Juntendo University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"De Minicis","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Politecnica delle Marche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Bataller","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Brenner","sequence":"additional","affiliation":[{"name":"University of California San Diego, La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1507-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20719"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2006496"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.113456"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406486200"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/192543"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25938"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22708"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50087"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2522"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-011-0276-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200613200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17558"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70368-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.018"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1346"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18212"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2007.021"},{"key":"e_1_3_2_21_2","first-page":"4","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly","author":"Beckman JS","year":"1996","unstructured":"Beckman JS, and Koppenol WH. 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