{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:12:48Z","timestamp":1792955568922,"version":"4.5.0"},"reference-count":221,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    Targeted irradiation is an effective cancer therapy but damage inflicted to normal tissues surrounding the tumor may cause severe complications. While certain pharmacologic strategies can temper the adverse effects of irradiation, stem cell therapies provide unique opportunities for restoring functionality to the irradiated tissue bed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    Preclinical studies presented in this review provide encouraging proof of concept regarding the therapeutic potential of stem cells for treating the adverse side effects associated with radiotherapy in different organs. Early-stage clinical data for radiation-induced lung, bone, and skin complications are promising and highlight the importance of selecting the appropriate stem cell type to stimulate tissue regeneration.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    While therapeutic efficacy has been demonstrated in a variety of animal models and human trials, a range of additional concerns regarding stem cell transplantation for ameliorating radiation-induced normal tissue sequelae remain. Safety issues regarding teratoma formation, disease progression, and genomic stability along with technical issues impacting disease targeting, immunorejection, and clinical scale-up are factors bearing on the eventual translation of stem cell therapies into routine clinical practice.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    Follow-up studies will need to identify the best possible stem cell types for the treatment of early and late radiation-induced normal tissue injury. Additional work should seek to optimize cellular dosing regimes, identify the best routes of administration, elucidate optimal transplantation windows for introducing cells into more receptive host tissues, and improve immune tolerance for longer-term engrafted cell survival into the irradiated microenvironment.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    21: 338\u2013355.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5652","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T09:51:43Z","timestamp":1382435503000},"page":"338-355","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":93,"title":["Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects"],"prefix":"10.1177","volume":"21","author":[{"given":"Marc","family":"Benderitter","sequence":"first","affiliation":[{"name":"IRSN","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Caviggioli","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Chapel","sequence":"additional","affiliation":[{"name":"IRSN","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Coppes","sequence":"additional","affiliation":[{"name":"University of Groningen","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Guha","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Klinger","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Malard","sequence":"additional","affiliation":[{"name":"Nantes University Hospital","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Stewart","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radia","family":"Tamarat","sequence":"additional","affiliation":[{"name":"IRSN","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van Luijk","sequence":"additional","affiliation":[{"name":"University of Groningen","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Limoli","sequence":"additional","affiliation":[{"name":"University of California Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909293106"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0027"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X640565"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00026-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7765"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/532704"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9912"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2217\/rme.11.22"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70026-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0623"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200310000-00010"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0179"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/3579813"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706760104"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0156-06.2006"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e3181c9f79a"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901402106"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.042"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0063-4"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61590-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1586\/eci.10.20"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.5816"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.19.3339"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.226"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.11.011"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.016"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038366"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-006-0026-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.122"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006375107"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31821e70e7"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.452"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.11.023"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.05.100"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.048"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.040"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67887-7"},{"key":"e_1_3_2_40_2","first-page":"CD006536","article-title":"Stem cell treatment for acute myocardial infarction","volume":"2","author":"Clifford DM","year":"2012","unstructured":"Clifford DM, , Fisher SA, , Brunskill SJ, , Doree C, , Mathur A, et al. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev, 2: CD006536, 2012.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-007-0098-0"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR1821.1"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01723.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.11.005"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2009.11.005"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03750.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139337"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.064"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760020601"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.10.037"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.090"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.08.021"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2006.11.006"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23204"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0608-2"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(19990901)256:1<84::AID-AR11>3.0.CO;2-S"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0130"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.11.011"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70231-1"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70204-2"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200010000-00015"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.178962"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.143"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90171-Y"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.10.051"},{"key":"e_1_3_2_66_2","first-page":"312","volume-title":"Radiation Pathology","author":"Fajardo LF","year":"2001","unstructured":"Fajardo LF, , Berthrong M, , and Anderson RE. Testis. In Radiation Pathology, New York: Oxford University Press, 2001:312\u2013318."},{"key":"e_1_3_2_67_2","first-page":"584","article-title":"Pathogenesis of veno-occlusive liver disease after radiation","volume":"104","author":"Fajardo LF","year":"1980","unstructured":"Fajardo LF, and Colby TV. Pathogenesis of veno-occlusive liver disease after radiation. Arch Pathol Lab Med, 104: 584\u2013588, 1980.","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.06.023"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2006.10.010"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.12.003"},{"key":"e_1_3_2_71_2","unstructured":"Fox IJ. Hepatocyte Transplantation for Liver Based Metabolic Diosorders. NCT01345578 2011."},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.684378"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0260"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-006-0166-5"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1433"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2011.616194"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3302"},{"key":"e_1_3_2_79_2","first-page":"169","volume-title":"Oxidative Stress in Applied Basic Research and Clinical Practice: Cancer","author":"Globus RK","year":"2012","unstructured":"Globus RK, , Caiozzo VJ, , Acharya MM, , Fike JR, , and Limoli CL. Redox regulation of stem cell compartments: the convergence of radiation-induced normal tissue damage and oxidative stress. In: Oxidative Stress in Applied Basic Research and Clinical Practice: Cancer, edited by Spitz DR, , Dornfeld KJ, , Gius D, , and Krishnan K. Totowa, NJ: Humana Press, Inc., 2012, pp. 169\u2013192."},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.05.012"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00576-9"},{"key":"e_1_3_2_82_2","first-page":"391","article-title":"[Bone marrow autograft. Current status and perspectives]","volume":"25","author":"Gorin NC","year":"1983","unstructured":"Gorin NC. [Bone marrow autograft. Current status and perspectives]. Nouv Rev Fr Hematol, 25: 391\u2013399, 1983 [Article in French].","journal-title":"Nouv Rev Fr Hematol"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.02.004"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.11.006"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00177-7"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2011.05.003"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34516"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01495-4"},{"key":"e_1_3_2_89_2","first-page":"5871","article-title":"Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation","volume":"59","author":"Guha C","year":"1999","unstructured":"Guha C, , Sharma A, , Gupta S, , Alfieri A, , Gorla GR, et al. Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Res, 59: 5871\u20135874, 1999.","journal-title":"Cancer Res"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085408"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300480-7"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014925.09415.C3"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S25665"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139880502800111"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1549"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408258102"},{"key":"e_1_3_2_97_2","first-page":"200","article-title":"Radiation hepatitis","volume":"93","author":"Ingold JA","year":"1965","unstructured":"Ingold JA, , Reed GB, , Kaplan HS, , and Bagshaw MA. Radiation hepatitis. Am J Roentgenol Radium Ther Nucl Med, 93: 200\u2013208, 1965.","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816de49e"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-011-0116-z"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1903"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.131"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05776.x"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000046450.89986.50"},{"key":"e_1_3_2_104_2","first-page":"1142","article-title":"A study of irradiated bone: I. histopathologic and physiologic changes","volume":"20","author":"King MA","year":"1979","unstructured":"King MA, , Casarett GW, , and Weber DA. A study of irradiated bone: I. histopathologic and physiologic changes. J Nucl Med, 20: 1142\u20131149, 1979.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181e3b585"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.559"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.37"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.2217\/rme.12.51"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192046"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3163"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.051"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.035"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1080\/0891060310002168"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.09091"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-009-0538-7"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-199602000-00005"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.6647"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00418-K"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60690-X"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200202000-00009"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.6.1124"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510386374"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.12.005"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.07.010"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002063"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1449"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-1034"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01783.x"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9153-8"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488809787169093"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2005.02.001"},{"key":"e_1_3_2_132_2","unstructured":"Malard O. Curative Treatment of Osteoradionecrosis (ORN) with Hybrid Bone Substitution. Clinicaltrialsgov NCT01147315 2013."},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192365499"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.3.2.165"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225804"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2009.05.011"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01858.x"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0214"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.029"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(83)90294-X"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.06.016"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2006.04.004"},{"key":"e_1_3_2_143_2","first-page":"75","article-title":"Neurocognitive dysfunction in cancer patients","volume":"14","author":"Meyers CA","year":"2000","unstructured":"Meyers CA. Neurocognitive dysfunction in cancer patients. Oncology (Williston Park), 14: 75\u201379; discussion 79, 81\u201372, 85, 2000.","journal-title":"Oncology (Williston Park)"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060116"},{"key":"e_1_3_2_145_2","first-page":"4021","article-title":"Extreme sensitivity of adult neurogenesis to low doses of X-irradiation","volume":"63","author":"Mizumatsu S","year":"2003","unstructured":"Mizumatsu S, , Monje M, , Morhardt D, , Rola R, , Palmer T, et al. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res, 63: 4021\u20134027, 2003.","journal-title":"Cancer Res"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/25927054"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-468-1_15"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000558"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1188\/09.CJON.413-421"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6306-2_9"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00862-0"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.085"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2008.01.003"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"e_1_3_2_155_2","first-page":"240","article-title":"Hepatic injury following irradiation\u2014a morphologic study","volume":"43","author":"Ogata K","year":"1963","unstructured":"Ogata K, , Hizawa K, , Yoshida M, , Kitamuro T, , Akagi G, et al. Hepatic injury following irradiation\u2014a morphologic study. Tokushima J Exp Med, 43: 240\u2013251, 1963.","journal-title":"Tokushima J Exp Med"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1522-1865(03)00182-3"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsl056"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2011.10.002"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.092"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060191"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2007.09.004"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(96)00048-2"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014550431"},{"key":"e_1_3_2_164_2","first-page":"35","article-title":"Normal tissue protection for improving radiotherapy: where are the Gaps?","volume":"1","author":"Prasanna PG","year":"2012","unstructured":"Prasanna PG, , Stone HB, , Wong RS, , Capala J, , Bernhard EJ, et al. Normal tissue protection for improving radiotherapy: where are the Gaps?. Transl Cancer Res, 1: 35\u201348, 2012.","journal-title":"Transl Cancer Res"},{"key":"e_1_3_2_165_2","first-page":"2484","article-title":"Isolation of mouse salivary gland stem cells","author":"Pringle S","year":"2011","unstructured":"Pringle S, , Nanduri LS, , van der Zwaag M, , van Os R, , and Coppes RP. Isolation of mouse salivary gland stem cells. J Vis Exp, pii: 2484, 2011.","journal-title":"J Vis Exp"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1327"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60075-0"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3206"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-398459-3.00003-4"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.059"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/234975"},{"key":"e_1_3_2_172_2","first-page":"597","article-title":"The human liver after radiation injury. A form of veno-occlusive disease","volume":"48","author":"Reed GB","year":"1966","unstructured":"Reed GBJr., , and Cox AJJr., The human liver after radiation injury. A form of veno-occlusive disease. Am J Pathol, 48: 597\u2013611, 1966.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2011-0019"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1553558"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2001)156[0408:MORMBT]2.0.CO;2"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000256047.47909.71"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.09.058"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.05.005"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024072"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.07012"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.07.004"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00655-5"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-65-777-737"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90046-6"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214550761"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.08.071"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-34133-0_2"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.187"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.12.005"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2012.02349.x"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90204-P"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050409"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.11.011"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-219907"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.025"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004579"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2000)153[0357:TROTCN]2.0.CO;2"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.459"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.10.010"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.2267"},{"key":"e_1_3_2_202_2","first-page":"207","article-title":"Radiation-induced damage in the central nervous system: an interpretation of target cell responses","volume":"7","author":"van der Kogel AJ","year":"1986","unstructured":"van der Kogel AJ. Radiation-induced damage in the central nervous system: an interpretation of target cell responses. Br J Cancer Suppl, 7: 207\u2013217, 1986.","journal-title":"Br J Cancer Suppl"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1038\/4151030a"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.07.059"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400305"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8347-6"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.1990"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.560567"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1124\/mi.4.5.7"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22573"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.589937"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.10.015"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn081"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-008-9256-9"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20575"},{"key":"e_1_3_2_216_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21859"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.09.036"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787002790"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.541"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr148"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2013.5652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:46Z","timestamp":1777377226000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2013.5652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":221,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1089\/ars.2013.5652"],"URL":"https:\/\/doi.org\/10.1089\/ars.2013.5652","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}