{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:56:00Z","timestamp":1793786160011,"version":"4.6.1"},"reference-count":76,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    <\/jats:bold>\n                    Storkhead box 1 (STOX1) is a winged-helix transcription factor that is implicated in the genetic forms of a high-prevalence human gestational disease, pre-eclampsia.\n                    <jats:italic toggle=\"yes\">STOX1<\/jats:italic>\n                    overexpression confers pre-eclampsia-like transcriptomic features to trophoblastic cell lines and pre-eclampsia symptoms to pregnant mice. The aim of this work was to evaluate the impact of STOX1 on free radical equilibrium and mitochondrial function, both\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    .\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Transcriptome analysis of STOX1-transgenic\n                    <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                    nontransgenic placentas at 16.5 days of gestation revealed alterations of mitochondria-related pathways. Placentas overexpressing STOX1 displayed altered mitochondrial mass and were severely biased toward protein nitration, indicating nitroso-redox imbalance\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . Trophoblast cells overexpressing STOX1 displayed an increased mitochondrial activity at 20% O\n                    <jats:sub>2<\/jats:sub>\n                    and in hypoxia, despite reduction of the mitochondrial mass in the former. STOX1 overexpression is, therefore, associated with hyperactive mitochondria, resulting in increased free radical production. Moreover, nitric oxide (NO) production pathways were activated, resulting in peroxynitrite formation. At low oxygen pressure, STOX1 overexpression switched the free radical balance from reactive oxygen species (ROS) to reactive nitrogen species (RNS) in the placenta as well as in a trophoblast cell line.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation:<\/jats:italic>\n                    <\/jats:bold>\n                    In pre-eclamptic placentas, NO interacts with ROS and generates peroxynitrite and nitrated proteins as end products. This process will deprive the maternal organism of NO, a crucial vasodilator molecule.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Our data posit STOX1 as a genetic switch in the ROS\/RNS balance and suggest an explanation for elevated blood pressure in pre-eclampsia.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    21, 819\u2013834.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5661","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T11:31:37Z","timestamp":1397647897000},"page":"819-834","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":84,"title":["Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by\n                    <i>STOX1<\/i>\n                    , a Pre-Eclampsia-Associated Gene"],"prefix":"10.1177","volume":"21","author":[{"given":"Ludivine","family":"Doridot","sequence":"first","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Ch\u00e2tre","sequence":"additional","affiliation":[{"name":"Institut Pasteur","place":["France"]},{"name":"Team Stability of Nuclear and Mitochondrial DNA","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Ducat","sequence":"additional","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Vilotte","sequence":"additional","affiliation":[{"name":"Institut Nationale de la Recherche Agronomique","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lomb\u00e8s","sequence":"additional","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"M\u00e9hats","sequence":"additional","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Barbaux","sequence":"additional","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamaria","family":"Calicchio","sequence":"additional","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miria","family":"Ricchetti","sequence":"additional","affiliation":[{"name":"Institut Pasteur","place":["France"]},{"name":"Team Stability of Nuclear and Mitochondrial DNA","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vaiman","sequence":"additional","affiliation":[{"name":"Institut Cochin","place":["France"]},{"name":"Facult\u00e9 Paris Descartes","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-008-9143-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000110785.96039.f6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719110361960"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.11.027"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01414.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr045"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.695823"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441209"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.08.020"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0815"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/684384"},{"key":"e_1_3_3_14_2","first-page":"914","article-title":"Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging","volume":"126","author":"Chatre L","year":"2012","unstructured":"Chatre L, and Ricchetti M. 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