{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:14:31Z","timestamp":1791497671393,"version":"4.3.4"},"reference-count":194,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    There is increasing evidence that the generation of reactive oxygen species (ROS) in the central nervous system (CNS) involves the NOX family of nicotinamide adenine dinucleotide phosphate oxidases. Controlled ROS generation appears necessary for optimal functioning of the CNS through fine-tuning of redox-sensitive signaling pathways, while overshooting ROS generation will lead to oxidative stress and CNS disease.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    NOX enzymes are not only restricted to microglia (\n                    <jats:italic toggle=\"yes\">i.e.<\/jats:italic>\n                    brain phagocytes) but also expressed in neurons, astrocytes, and the neurovascular system. NOX enzymes are involved in CNS development, neural stem cell biology, and the function of mature neurons. While NOX2 appears to be a major source of pathological oxidative stress in the CNS, other NOX isoforms might also be of importance, for example, NOX4 in stroke. Globally speaking, there is now convincing evidence for a role of NOX enzymes in various neurodegenerative diseases, cerebrovascular diseases, and psychosis-related disorders.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    The relative importance of specific ROS sources (\n                    <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                    , NOX enzymes\n                    <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                    mitochondria; NOX2\n                    <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                    NOX4) in different pathological processes needs further investigation. The absence of specific inhibitors limits the possibility to investigate specific therapeutic strategies. The uncritical use of non-specific inhibitors (\n                    <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                    , apocynin, diphenylene iodonium) and poorly validated antibodies may lead to misleading conclusions.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    Physiological and pathophysiological studies with cell-type-specific knock-out mice will be necessary to delineate the precise functions of NOX enzymes and their implications in pathomechanisms. The development of CNS-permeant, specific NOX inhibitors will be necessary to advance toward therapeutic applications.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    20: 2815\u20132837.\n                  <\/jats:p>","DOI":"10.1089\/ars.2013.5703","type":"journal-article","created":{"date-parts":[[2013,11,10]],"date-time":"2013-11-10T06:09:28Z","timestamp":1384063768000},"page":"2815-2837","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":265,"title":["New Insights on\n                    <i>NOX<\/i>\n                    Enzymes in the Central Nervous System"],"prefix":"10.1177","volume":"20","author":[{"given":"Zeynab","family":"Nayernia","sequence":"first","affiliation":[{"name":"Centre M\u00e9dical Universitaire","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jaquet","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dical Universitaire","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Krause","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dical Universitaire","place":["Switzerland"]},{"name":"Geneva University Hospitals","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227901"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(99)00113-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1010-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.07.023"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.03.025"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9164-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6055"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21029"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.11.023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148045"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4457-08.2008"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-33"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.156521"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar100059g"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3339"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22038"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920112798868782"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2334"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.07.012"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.03.006"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255216"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5157-10.2011"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3895"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.515"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00974.2012"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4585"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.01.027"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200709049"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00449-8"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3568-08.2008"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760400027987"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.09.015"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3960"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07572.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.05.004"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1333875"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00035-1"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4489"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.03.009"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2459"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2246-12.2012"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.016"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000368"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.497"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-41"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005518"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/234631"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.01.077"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.05.030"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22437"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws012"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2587"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.089706"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080421"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000370"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-08-0685"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00966.2005"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0795"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4189"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.07.006"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr128"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"e_1_3_2_69_2","first-page":"659","article-title":"SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model","volume":"118","author":"Harraz MM","year":"2008","unstructured":"Harraz MM, , Marden JJ, , Zhou W, , Zhang Y, , Williams A, , Sharov VS, , Nelson K, , Luo M, , Paulson H, , Schoneich C, , and Engelhardt JF. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest, 118: 659\u2013670, 2008.","journal-title":"J Clin Invest"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00071"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.100214"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.100.418.29"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4734"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023945"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.009"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.010"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403831101"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4136-11.2011"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000187472.55437.af"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908164"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.168"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00801.x"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2585"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds472"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.33"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760902918683"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4721"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6227-11.2012"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3318"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2534"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009926107"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0790-7"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.01.066"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00269-06"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000479"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.06.016"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121778"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.236"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.11.013"},{"key":"e_1_3_2_100_2","first-page":"226","article-title":"Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease","volume":"1","author":"Labandeira-Garcia JL","year":"2012","unstructured":"Labandeira-Garcia JL, , Rodriguez-Pallares J, , Rodriguez-Perez AI, , Garrido-Gil P, , Villar-Cheda B, , Valenzuela R, , and Guerra MJ. Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease. Am J Neurodegener Dis, 1: 226\u2013244, 2012.","journal-title":"Am J Neurodegener Dis"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-97"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243972"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.028"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2832-12.2013"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22540"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2637"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235563"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.279711"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.06.011"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2006.10.002"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.557"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00546"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328356d328"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020153"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.002"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22240"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0400139"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-0102ufm"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31265"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3155"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00069-8"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1177\/1470320309347789"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-1-200501040-00110"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20957"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0430-7"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7516"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.25334"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019847"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.09.068"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0347-4"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-j0001.2000"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2900041"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.45.3.230"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.140087"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/401264"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.09.036"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22479"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4797"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115141108"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(96)90143-X"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1597-12.2012"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8465-z"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3635"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(09)85024-1"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-008-0119-2"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.36"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4720"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.04.033"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.598326"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061903"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03364-X"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4106"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23569"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-010-8107-7"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10540"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.04.015"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1147"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2578"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1014-5"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1491-10.2010"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.008"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.04.013"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1015-4"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008200802143166"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21464"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-011-0238-3"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.192138"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-2-24"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508886102"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02517"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.07.015"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.04.031"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds516"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)61021-2"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-156"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2004.12.008"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.11.2252"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.08.003"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000236647.55200.07"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00367.2012"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4907"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.09.001"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1159\/000321547"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1107-1"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.07.001"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603670103"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3059"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01445-09"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.05.016"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.1.12"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00595.x"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2009.11.018"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.09.003"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034504"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.488"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2013.5703","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2013.5703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:52:52Z","timestamp":1777377172000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2013.5703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":194,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1089\/ars.2013.5703"],"URL":"https:\/\/doi.org\/10.1089\/ars.2013.5703","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}