{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:43:09Z","timestamp":1790883789296,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>\n                    The aim of this study was to investigate in a case\u2013control study the associations between idiopathic infertility and antioxidant gene polymorphisms. One hundred ten infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no history of infertility were included by three hospital departments of reproductive biology in the NCT01093378 French government clinical trial. Genotyping was assessed by real-time polymerase chain reaction with TaqMan assay. We examined genetic polymorphisms affecting five antioxidant enzymes: manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), glutathione peroxidase 1 (GPx1), catalase (CAT), and endothelial nitric oxide synthase (eNOS). The presence of at least 1 Ala-MnSOD allele (rs4880) increased significantly the risk of infertility (odds ratio [OR] 2.94; 95% confidence interval [CI], 1.14, 7.60;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.03) in male subjects. Moreover, the presence of 2 G-\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    allele (rs1799983) increased significantly the risk of infertility in both men and women (OR 1.91; 95% CI, 1.04, 3.54;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.04). Our observations lead to the hypothesis that the genetic susceptibility modulating oxidative stress may represent a risk factor for male idiopathic infertility.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    21, 565\u2013569.\n                  <\/jats:p>","DOI":"10.1089\/ars.2014.5831","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T09:46:31Z","timestamp":1390211191000},"page":"565-569","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Are Superoxide Dismutase 2 and Nitric Oxide Synthase Polymorphisms Associated with Idiopathic Infertility?"],"prefix":"10.1177","volume":"21","author":[{"given":"Celine","family":"Faure","sequence":"first","affiliation":[{"name":"H\u00f4pital Jean Verdier","place":["France"]},{"name":"Universit\u00e9 Paris 13","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Leveille","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jean Verdier","place":["France"]},{"name":"Universit\u00e9 Paris 13","place":["France"]},{"name":"INRA","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Dupont","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jean Verdier","place":["France"]},{"name":"Universit\u00e9 Paris 13","place":["France"]},{"name":"INRA","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Julia","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 13","place":["France"]},{"name":"H\u00f4pital Avicenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Chavatte-Palmer","sequence":"additional","affiliation":[{"name":"INRA","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alifert Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sutton","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jean-Verdier","place":["France"]},{"name":"UFR SMBH, Universit\u00e9 Paris 13","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Levy","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jean Verdier","place":["France"]},{"name":"Universit\u00e9 Paris 13","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-49"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3186"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008979"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.04.011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.11.032"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00123.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.08.012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.10.018"},{"key":"e_1_3_2_10_2","first-page":"219","article-title":"Studies on free radicals, antioxidants, and co-factors","volume":"2","author":"Rahman K","year":"2007","unstructured":"Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging, 2: 219\u2013236, 2007.","journal-title":"Clin Interv Aging"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2014.5831","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2014.5831","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2014.5831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:52Z","timestamp":1777377232000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2014.5831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1089\/ars.2014.5831"],"URL":"https:\/\/doi.org\/10.1089\/ars.2014.5831","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}