{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:23:05Z","timestamp":1791177785082,"version":"4.1.0"},"reference-count":196,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    Although oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    )-sensing cells and tissues have been known for decades, the identity of the O\n                    <jats:sub>2<\/jats:sub>\n                    -sensing mechanism has remained elusive. Evidence is accumulating that O\n                    <jats:sub>2<\/jats:sub>\n                    -dependent metabolism of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is this enigmatic O\n                    <jats:sub>2<\/jats:sub>\n                    sensor.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    The elucidation of biochemical pathways involved in H\n                    <jats:sub>2<\/jats:sub>\n                    S synthesis and metabolism have shown that reciprocal H\n                    <jats:sub>2<\/jats:sub>\n                    S\/O\n                    <jats:sub>2<\/jats:sub>\n                    interactions have been inexorably linked throughout eukaryotic evolution; there are multiple foci by which O\n                    <jats:sub>2<\/jats:sub>\n                    controls H\n                    <jats:sub>2<\/jats:sub>\n                    S inactivation, and the effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S on downstream signaling events are consistent with those activated by hypoxia. H\n                    <jats:sub>2<\/jats:sub>\n                    S-mediated O\n                    <jats:sub>2<\/jats:sub>\n                    sensing has been demonstrated in a variety of O\n                    <jats:sub>2<\/jats:sub>\n                    -sensing tissues in vertebrate cardiovascular and respiratory systems, including smooth muscle in systemic and respiratory blood vessels and airways, carotid body, adrenal medulla, and other peripheral as well as central chemoreceptors.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    Information is now needed on the intracellular location and stoichometry of these signaling processes and how and which downstream effectors are activated by H\n                    <jats:sub>2<\/jats:sub>\n                    S and its metabolites.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    Development of specific inhibitors of H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism and effector activation as well as cellular organelle-targeted compounds that release H\n                    <jats:sub>2<\/jats:sub>\n                    S in a time- or environmentally controlled way will not only enhance our understanding of this signaling process but also provide direction for future therapeutic applications.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                    . 22, 377\u2013397.\n                  <\/jats:p>","DOI":"10.1089\/ars.2014.5930","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T03:18:29Z","timestamp":1399432709000},"page":"377-397","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":120,"title":["Hydrogen Sulfide as an Oxygen Sensor"],"prefix":"10.1177","volume":"22","author":[{"given":"Kenneth R.","family":"Olson","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine\u2014South Bend","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.044"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12171"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.08.037"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00718.2012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00555.2010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408448409029321"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.031905.162529"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108581"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31802e27a0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3678"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01480.x"},{"key":"e_1_3_2_14_2","first-page":"e36","article-title":"Cystathionine gamma-lyase-deficient smooth muscle cells exhibit redox imbalance and apoptosis under hypoxic stress conditions","volume":"16","author":"Bryan S","year":"2011","unstructured":"Bryan S, , Yang G, , Wang R, , and Khaper N. 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