{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:40:59Z","timestamp":1777434059344,"version":"3.51.4"},"reference-count":209,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    Over-nutrition and sedentary lifestyle has led to a worldwide increase in obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of development of cardiovascular disorders. Diabetic cardiomyopathy, independent of hypertension or coronary disease, is induced by a range of systemic changes and may through multiple processes result in functional and structural cardiac derangements. The pathogenesis of this cardiomyopathy is complex and multifactorial, and it will eventually lead to reduced cardiac working capacity and increased susceptibility to ischemic injury.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    Metabolic disturbances such as altered lipid handling and substrate utilization, decreased mechanical efficiency, mitochondrial dysfunction, disturbances in nonoxidative glucose pathways, and increased oxidative stress are hallmarks of diabetic cardiomyopathy. Interestingly, several of these disturbances are found to precede the development of cardiac dysfunction.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    Exercise training is effective in the prevention and treatment of obesity and T2D. In addition to its beneficial influence on diabetes\/obesity-related systemic changes, it may also amend many of the metabolic disturbances characterizing the diabetic myocardium. These changes are due to both indirect effects, exercise-mediated systemic changes, and direct effects originating from the high contractile activity of the heart during physical training.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    Revealing the molecular mechanisms behind the beneficial effects of exercise training is of considerable scientific value to generate evidence-based therapy and in the development of new treatment strategies.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    22, 1587\u20131605.\n                  <\/jats:p>","DOI":"10.1089\/ars.2015.6304","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T15:35:10Z","timestamp":1425483310000},"page":"1587-1605","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy"],"prefix":"10.1177","volume":"22","author":[{"given":"Anne D.","family":"Hafstad","sequence":"first","affiliation":[{"name":"UiT\u2014The Arctic University of Norway","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neoma","family":"Boardman","sequence":"additional","affiliation":[{"name":"UiT\u2014The Arctic University of Norway","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Aasum","sequence":"additional","affiliation":[{"name":"UiT\u2014The Arctic University of Norway","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.434"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.07.016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00251.2013"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(03)00110-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.031"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00932.2010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2741\/3443"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.164277"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.02.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.050"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.04.076"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2082"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2559"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.270538"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00147.2011"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-004-0035-3"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.5.E1104"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.12.3201"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.09.007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2.463"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00103.2008"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0144-x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(49)90788-7"},{"key":"e_1_3_2_25_2","first-page":"CD007176","article-title":"Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases","volume":"3","author":"Bjelakovic G","year":"2008","unstructured":"Bjelakovic G, , Nikolova D, , Gluud LL, , Simonetti RG, , and Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev, 3: CD007176, 2008.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199911001-00025"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.12.033"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01264.2008"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01190.2010"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.05.025"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070248"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0063"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.554360"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0481"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.1.82"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603952200"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.04.022"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.479"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0938"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00925.2003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255216"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.261.3.H741"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1385\/CT:3:3:219"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000065620.39919.20"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4501.098928"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4824"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1076"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00456.2007"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000154079.20681.B9"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10947"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1951"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2002.00716.x"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303810200"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0156-1"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.765750"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.11.007"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-101"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2006.00077.x"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900365"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.009"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208262200"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0294"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2010"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12537"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0739"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2375"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00877091"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214080"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.254193"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00548.2011"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.12.1123"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1763"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833366cd"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)36768-0"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp031"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2295"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113822"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0195g.x"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/972807"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.621854"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00055.2005"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-7-34"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00594.2011"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00504.2006"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1580"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0359-8"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-4"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-234914"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119390"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10758"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.10.007"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180304570"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01908314"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.971"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.02.06.db05-1164"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1080\/13813450701783281"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000165478.06813.58"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808518200"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.03.002"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00070-4"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072080"},{"key":"e_1_3_2_103_2","first-page":"H723","article-title":"Effect of fatty acid oxidation on efficiency of energy production in rat heart","volume":"249","author":"Hutter JF","year":"1985","unstructured":"Hutter JF, , Piper HM, , and Spieckerman PG. Effect of fatty acid oxidation on efficiency of energy production in rat heart. Am J Physiol, 249: H723\u2013H728, 1985.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.01.003"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.11059"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0070136"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.074"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121631"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.6.1414"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000024413.15949.ED"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.03.010"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00551.2004"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P028910"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.013"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00292"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.328708"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00133-14"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00826.2007"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018417"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.737463"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.02.008"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01198.2011"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1800"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0213-9"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.174"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.09.015"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.049817"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M024208"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01626.2011"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2009"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2106-3"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.06.011"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01059.2012"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.08.006"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22387"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.04.030"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00135.2013"},{"key":"e_1_3_2_138_2","first-page":"97","article-title":"Exercise mitigates homocysteine - beta2-adrenergic receptor interactions to ameliorate contractile dysfunction in diabetes","volume":"3","author":"Mishra PK","year":"2011","unstructured":"Mishra PK, , Awe O, , Metreveli N, , Qipshidze N, , Joshua IG, , and Tyagi SC. Exercise mitigates homocysteine - beta2-adrenergic receptor interactions to ameliorate contractile dysfunction in diabetes. Int J Physiol Pathophysiol Pharmacol, 3: 97\u2013106, 2011.","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106621"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.010"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.005"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-55"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3496"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.440"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011858"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9186-2"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2190"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00553.2009"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.09.001"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.08.002"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363207"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm029"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.156141"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.1.265"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2429"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127959.28627.F8"},{"key":"e_1_3_2_157_2","first-page":"48","article-title":"Heart mitochondrial function in chronic experimental diabetes in rats","volume":"1","author":"Pierce GN","year":"1985","unstructured":"Pierce GN, and Dhalla NS. Heart mitochondrial function in chronic experimental diabetes in rats. Can J Cardiol, 1: 48\u201354, 1985.","journal-title":"Can J Cardiol"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371824"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.02.006"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1320"},{"key":"e_1_3_2_161_2","first-page":"90","article-title":"Adaptation to exercise-induced oxidative stress: from muscle to brain","volume":"7","author":"Radak Z","year":"2001","unstructured":"Radak Z, , Taylor AW, , Ohno H, , and Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev, 7: 90\u2013107, 2001.","journal-title":"Exerc Immunol Rev"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00564.x"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-007-0018-3"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9622-3"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00426-14"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.062"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903485106"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.05.007"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.101444"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm011"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5262"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072789.89096.10"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2076"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-10-47"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000064585.95749.6D"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M043448"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91280.2008"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00525.2010"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.03.06.db05-1039"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00047.2004"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40096"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-008-0006-6"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.02.009"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02772-9"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199810"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04684.x"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.2.247"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1164"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00137.2010"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.05.004"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.772822"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0072"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.07.029"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.645184"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.06.030"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00101.2013"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.09.005"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9320"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.014"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001907107"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-092576"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp017"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.11.006"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.832915"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.5.1336"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021371"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.04.007"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-009-0126-3"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq266"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214442"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2015.6304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2015.6304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2015.6304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:52:43Z","timestamp":1777377163000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2015.6304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":209,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1089\/ars.2015.6304"],"URL":"https:\/\/doi.org\/10.1089\/ars.2015.6304","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}