{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:31:50Z","timestamp":1787614310477,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    <\/jats:bold>\n                    To explore the molecular connections between redox-dependent apoptosis signal-regulating kinase 1 (ASK1) and transforming growth factor-\u03b2 (TGF-\u03b2) signaling pathways and to examine the physiological processes in which coordinated regulation of these two signaling pathways plays a critical role.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    We provide evidence that the ASK1 and TGF-\u03b2 signaling pathways are interconnected by a multiprotein complex harboring murine protein serine\u2013threonine kinase 38 (MPK38), ASK1, Sma- and Mad-related proteins (SMADs), zinc-finger-like protein 9 (ZPR9), and thioredoxin (TRX) and demonstrate that the activation of either ASK1 or TGF-\u03b2 activity is sufficient to activate both the redox-dependent ASK1 and TGF-\u03b2 signaling pathways. Physiologically, the restoration of the downregulated activation levels of ASK1 and TGF-\u03b2 signaling in genetically and diet-induced obese mice by adenoviral delivery of SMAD3 or ZPR9 results in the amelioration of adiposity, hyperglycemia, hyperlipidemia, and impaired ketogenesis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation and Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Our data suggest that the multiprotein complex linking ASK1 and TGF-\u03b2 signaling pathways may be a potential target for redox-mediated metabolic complications.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                    . 24, 434\u2013452.\n                  <\/jats:p>","DOI":"10.1089\/ars.2015.6325","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T10:41:22Z","timestamp":1443609682000},"page":"434-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Coordinate Activation of Redox-Dependent ASK1\/TGF-\u03b2 Signaling by a Multiprotein Complex (MPK38, ASK1, SMADs, ZPR9, and TRX) Improves Glucose and Lipid Metabolism in Mice"],"prefix":"10.1177","volume":"24","author":[{"given":"Hyun-A","family":"Seong","sequence":"first","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjung","family":"Ha","sequence":"additional","affiliation":[{"name":"Chungbuk National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/936486"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00203.2010"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.14834"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212259200"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142727.mb2302s51"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.9.3157-3167.2000"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601752103"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.08.018"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705181200"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807219200"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.045229"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00470-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2559"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.12.002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000022160.64355.62"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.020"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101672200"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90996.2008"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780059607"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.14.2999"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2327"},{"key":"e_1_3_3_24_2","first-page":"1","article-title":"Pathophysiological roles of ASK1-MAP kinase signaling pathways","volume":"40","author":"Nagai H","year":"2007","unstructured":"Nagai H, , Noguchi T, , Takeda K, , and Ichijo H. 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