{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:09:41Z","timestamp":1779430181976,"version":"3.53.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    <\/jats:bold>\n                    Angiotensin II (Ang II) aggravates hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Angiotensin-(1\u20137) [Ang-(1\u20137)], which counter-regulates Ang II, has been evidenced to protect against hepatic fibrosis. The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, being activated by reactive oxygen species (ROS), is identified as a novel mechanism of liver fibrosis. However, whether the NLRP3 inflammasome involves in regulation of Ang II-induced hepatic fibrosis remains unclear. This study investigates the different effects of the Ang II and Ang-(1\u20137) on collagen synthesis by regulating the NLRP3 inflammasome\/Smad pathway\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    redox balance modulation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    , Ang-(1\u20137) improved bile duct ligation-induced hepatic fibrosis, reduced H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    content, protein levels of NOX4, and the NLRP3 inflammasome, whereas it increased glutathione (GSH) and nuclear erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE).\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    , Ang II treatment elevated NOX4 protein expression and ROS production in hepatic stellate cells (HSCs), whereas it inhibited GSH and Nrf2-ARE, resulting in the activation of the NLRP3 inflammasome in the mitochondria of HSCs. NLRP3 depletion inhibited Ang II-induced collagen synthesis. Furthermore, Ang II increased NLRP3 and pro-IL-1\u03b2 levels by activating the Toll-like receptor 4 (TLR4)\/MyD88\/NF-\u03baB pathway. Treatment with antioxidants, NOX4 small interference RNA (siRNA), or Nrf2 activator inhibited Ang II-induced NLRP3 inflammasome activation and collagen synthesis. In contrast, the action of Ang-(1\u20137) opposed the effects of Ang II.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Innovation and Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Ang-(1\u20137) improved liver fibrosis by regulating NLRP3 inflammasome activation induced by Ang II-mediated ROS\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    redox balance modulation.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    24, 795\u2013812.\n                  <\/jats:p>","DOI":"10.1089\/ars.2015.6498","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T07:07:49Z","timestamp":1451977669000},"page":"795-812","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":94,"title":["Angiotensin-(1\u20137) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome\n                    <i>via<\/i>\n                    Redox Balance Modulation"],"prefix":"10.1177","volume":"24","author":[{"given":"Shuang-Ming","family":"Cai","sequence":"first","affiliation":[{"name":"the Southern Medical University","place":["China"]},{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo-Wei","family":"Ning","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Su","family":"Zhou","sequence":"additional","affiliation":[{"name":"the Military General Hospital of Beijing PLA","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Huan","family":"Li","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Xia","family":"Pan","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"the Southern Medical University","place":["China"]},{"name":"the Southern Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406486200"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25938"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1346"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.07.023"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00307-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4918"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35384"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041316"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3058"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90564.2008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.05.007"},{"key":"e_1_3_3_13_2","first-page":"350","article-title":"Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery","volume":"9","author":"Kast RE","year":"2008","unstructured":"Kast RE. 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