{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:32:31Z","timestamp":1790224351274,"version":"4.1.0"},"reference-count":106,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Significance:<\/jats:italic>\n                    <\/jats:bold>\n                    Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Recent Advances:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this review is to critically evaluate the evidence for a role for H2S in kidney function and disease.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Critical Issues:<\/jats:italic>\n                    <\/jats:bold>\n                    H2S regulates fundamental kidney physiologic processes such as glomerular filtration and sodium reabsorption. In kidney disease states H2S appears to play a complex role in a context-dependent manner. In some disease states such as ischemia-reperfusion and diabetic kidney disease it can serve as an agent that ameliorates kidney injury. In other diseases such as cis-platinum-induced kidney disease it may mediate kidney injury although more investigation is needed. Recent studies have revealed that the actions of nitric oxide and H2S may be integrated in kidney cells.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Future Directions:<\/jats:italic>\n                    <\/jats:bold>\n                    Further studies are needed to understand the full impact of H2S on kidney physiology. As it is endowed with the properties of regulating blood flow, oxidative stress, and inflammation, H2S should be investigated for its role in inflammatory and toxic diseases of the kidney. Such in-depth exploration may identify specific kidney diseases in which H2S may constitute a unique target for therapeutic intervention.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    25, 720\u2013731.\n                  <\/jats:p>","DOI":"10.1089\/ars.2015.6596","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T22:02:38Z","timestamp":1458684158000},"page":"720-731","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":98,"title":["Hydrogen Sulfide in Renal Physiology and Disease"],"prefix":"10.1177","volume":"25","author":[{"given":"Denis","family":"Feliers","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center"},{"name":"South Texas Veterans Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakuntalam S.","family":"Kasinath","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center"},{"name":"South Texas Veterans Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,11,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00489.2014"},{"key":"e_1_3_3_3_2","first-page":"121","article-title":"Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat","volume":"5","author":"Ahangarpour A","year":"2014","unstructured":"Ahangarpour A, , Abdollahzade Fard A, , Gharibnaseri MK, , Jalali T, , and Rashidi I. 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