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In this study, we investigated molecular mechanisms underlying proresolving effects of 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      injected into the peritoneum of mice facilitated the resolution of zymosan A-induced peritonitis. 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      administration reduced the number of total leukocytes and attenuated polymorphonuclear leukocyte infiltration. Furthermore, 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      increased the proportion of macrophages engulfing apoptotic neutrophils, a process called efferocytosis. In addition, when the thioglycollate-elicited mouse peritoneal macrophages were stimulated with 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      , their efferocytic activity was amplified. In another experiment, RAW264.7 murine macrophages exposed to 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      conducted phagocytic clearance of apoptotic cells to a greater extent than the control cells. Under these conditions, expression of CD36 and heme oxygenase-1 (HO-1) was enhanced along with increased accumulation of the nuclear factor E2-related factor 2 (Nrf2) in the nucleus. Knockdown of\n                      <jats:italic toggle=\"yes\">Nrf2<\/jats:italic>\n                      abolished 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      -induced expression of CD36 and HO-1, and silencing of\n                      <jats:italic toggle=\"yes\">CD36<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">HO-1<\/jats:italic>\n                      attenuated 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      -induced efferocytosis. Moreover, peritoneal macrophages isolated from\n                      <jats:italic toggle=\"yes\">Nrf2<\/jats:italic>\n                      -null mice failed to upregulate 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      -induced expression of CD36 and HO-1 and to mediate efferocytosis. Unlike 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      , its nonelectrophilic analog 9,10-dihydro-15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      lacking the \u03b1,\u03b2-unsaturated carbonyl group could not induce CD36 expression and efferocytosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>\n                      15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      , as one of the terminal products of cyclooxygenase-2, exerts proresolving effects through induction of efferocytosis. The results of this study suggest that 15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      possesses a therapeutic value in the management of inflammatory disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      15d-PGJ\n                      <jats:sub>2<\/jats:sub>\n                      facilitates resolution of inflammation by inducing Nrf2-induced expression of CD36 and HO-1 in macrophages.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                      . 27, 1412\u20131431.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2016.6754","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T09:52:58Z","timestamp":1488361978000},"page":"1412-1431","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["15-Deoxy-\u0394\n                    <sup>12,14<\/sup>\n                    -Prostaglandin J\n                    <sub>2<\/sub>\n                    Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1"],"prefix":"10.1177","volume":"27","author":[{"given":"Wonki","family":"Kim","sequence":"first","affiliation":[{"name":"Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha-Na","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul 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