{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:39:10Z","timestamp":1788691150179,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants & Redox Signaling"],"published-print":{"date-parts":[[2017,2]]},"abstract":"\n Furosemide, a loop diuretic, is used to increase urine output in patients with acute kidney injury (AKI). It remains uncertain whether the benefits of furosemide in AKI outweigh its potential harms. We investigated if furosemide influenced oxidative stress in 30 critically ill patients with AKI by measuring changes in F\n 2<\/jats:sub>\n -isoprostanes (F\n 2<\/jats:sub>\n -IsoPs), markers of\n in vivo<\/jats:italic>\n oxidative stress, in plasma and urine following intravenous furosemide. Urine F\n 2<\/jats:sub>\n -IsoPs were higher in sepsis (\n p<\/jats:italic>\n \u2009=\u20090.001) and increased in proportion to urine furosemide (\n p<\/jats:italic>\n \u2009=\u20090.001). The furosemide-induced increase in urine F\n 2<\/jats:sub>\n -IsoPs differed depending on AKI severity (\n p<\/jats:italic>\n \u2009<\u20090.001) and was greatest in those with the most severe AKI. Furosemide had no effect on plasma F\n 2<\/jats:sub>\n -IsoPs. We demonstrate for the first time that furosemide increases renal oxidative stress in AKI and find that patients with the most severe AKI\u2014to whom the largest doses are likely to be administered\u2014showed the greatest increase in oxidative stress. These findings lead to the hypothesis that the common practice of administering high-dose furosemide to convert oliguric to nonoliguric AKI may induce harmful oxidative stress in the kidneys, and an adequately powered, randomized controlled trial is required to determine if clinical benefits of this dosing strategy justify its potential harms.\n Antioxid. Redox Signal.<\/jats:italic>\n 26, 221\u2013226.\n <\/jats:p>","DOI":"10.1089\/ars.2016.6845","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T22:39:28Z","timestamp":1471387168000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Does Furosemide Increase Oxidative Stress in Acute Kidney Injury?"],"prefix":"10.1177","volume":"26","author":[{"given":"Benjamin I.","family":"Silbert","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital","place":["Australia"]},{"name":"University of Western Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok M.","family":"Ho","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital","place":["Australia"]},{"name":"University of Western Australia","place":["Australia"]},{"name":"Murdoch University","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lipman","sequence":"additional","affiliation":[{"name":"University of Queensland","place":["Australia"]},{"name":"Royal Brisbane and Women's Hospital","place":["Australia"]},{"name":"Queensland University of Technology","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Queensland","place":["Australia"]},{"name":"Royal Brisbane and Women's Hospital","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas B.","family":"Corcoran","sequence":"additional","affiliation":[{"name":"University of Western Australia","place":["Australia"]},{"name":"Royal Perth Hospital","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Pavey","sequence":"additional","affiliation":[{"name":"Murdoch University","place":["Australia"]},{"name":"Fiona Stanley Hospital","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Mas","sequence":"additional","affiliation":[{"name":"University of Western Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Barden","sequence":"additional","affiliation":[{"name":"University of Western Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor A.","family":"Mori","sequence":"additional","affiliation":[{"name":"University of Western Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011090940"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02099.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06228.x"},{"key":"e_1_3_2_5_2","first-page":"251","article-title":"Diuretics in acute kidney injury","volume":"75","author":"Karajala V","year":"2009","unstructured":"Karajala V, , Mansour W, , and Kellum JA. Diuretics in acute kidney injury. Minerva Anestesiol, 75: 251\u2013257, 2009.","journal-title":"Minerva Anestesiol"},{"key":"e_1_3_2_6_2","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl, 2: 1\u2013138, 2012.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2330rev"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001823"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.10.028"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318217025a"}],"container-title":["Antioxidants & Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2016.6845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2016.6845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2016.6845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:14Z","timestamp":1777377254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2016.6845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1089\/ars.2016.6845"],"URL":"https:\/\/doi.org\/10.1089\/ars.2016.6845","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}