{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:16:30Z","timestamp":1791083790336,"version":"4.1.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Reactive sulfur species, including hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) and its oxydates, have been raised as novel redox signaling molecules. The present study aimed at examining whether endogenous sulfhydration signal is required for long-term potentiation (LTP), a cellular model for memory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In this study, we found that increased synaptic activity triggered sulfide generation and protein sulfhydration. Activity-triggered sulfide production was essential for N-methyl-D-aspartate subtype glutamate receptor (NMDAR)-dependent LTP\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      maintaining the availability of\n                      <jats:sc>d<\/jats:sc>\n                      -serine, a primary coagonist for synaptic NMDARs. Genetic knockdown of cystathionine\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      -synthase, not cystathionine\n                      <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                      -lyase, impaired LTP. H\n                      <jats:sub>2<\/jats:sub>\n                      S increased NMDAR-dependent LTP\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      sulfhydration and disinhibition of serine racemase (SR), a main synthetase of\n                      <jats:sc>d<\/jats:sc>\n                      -serine. We found that polysulfides also increased NMDAR-dependent LTP and NMDAR activity. In aged rats, the level of H\n                      <jats:sub>2<\/jats:sub>\n                      S and SR sulfhydration decreased significantly. Exogenous supplement of H\n                      <jats:sub>2<\/jats:sub>\n                      S restored the sulfhydration of SR, followed by the improvement of age-related deficits in LTP. Furthermore, boost of H\n                      <jats:sub>2<\/jats:sub>\n                      S signal\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      improves hippocampus-dependent memory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our results provide a direct evidence for the biological significance of endogenous sulfhydration signal in synaptic plasticity. Exogenous supplement of H\n                      <jats:sub>2<\/jats:sub>\n                      S could be considered as the new therapeutic approach for the treatment of neurocognitive dysfunction after aging.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      27, 398\u2013414.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2016.6936","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T11:22:41Z","timestamp":1483528961000},"page":"398-414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtype Glutamate Receptor-Dependent Synaptic Plasticity\n                    <i>via<\/i>\n                    Increasing\n                    <scp>d<\/scp>\n                    -Serine Availability"],"prefix":"10.1177","volume":"27","author":[{"given":"Yuan-Long","family":"Li","sequence":"first","affiliation":[{"name":"Huazhong University of Science and 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