{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:53:42Z","timestamp":1789966422438,"version":"4.0.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n                    Conventional cardiovascular risk factors (CVRFs) are accepted to identify asymptomatic individuals with high risk of acute myocardial infarction (AMI). However, AMI affects many patients previously classified at low risk. New biomarkers are needed to improve risk prediction. We propose to evaluate the NLRP3\u2013inflammasome complex as a potential conventional cardiovascular risk (CVR) indicator in healthy males and post-AMI patients and compare both groups by known CVRFs. We included 109 men with no history of cardiovascular disease (controls) and 150 AMI patients attending a cardiac rehabilitation program. AMI patients had higher mean of body mass index (BMI) and waist circumference than the controls. However, high percentages of the controls had a high BMI and a waist circumference &gt;95\u2009cm. The controls also had higher systolic blood pressure (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.001), total and low-density lipoprotein cholesterol, dietary nutrient, and calorific intake. Fuster BEWAT score (FBS) correlated more closely than Framingham risk score (FRS) with most CVRF, groups. However, only the FBS showed a correlation with inflammasome cytokine interleukin 1\u03b2 (IL-1\u03b2). Several CVRFs were significantly better in AMI patients; however, this group also had higher mRNA expression of the inflammasome gene\n                    <jats:italic toggle=\"yes\">NLRP3<\/jats:italic>\n                    and lower expression of the autophagy gene\n                    <jats:italic toggle=\"yes\">MAP-LC3<\/jats:italic>\n                    . The controls had high levels of CVRF, probably reflecting unhealthy lifestyle. FBS reflects the efficiency of strategies to induce lifestyle changes such as cardiac rehabilitation programs, and could provide a sensitive evaluation CVR. These results lead to the hypothesis that NLRP3\u2013inflammasome and associated IL-1\u03b2 release have potential as CVR biomarkers, particularly in post-AMI patients with otherwise low risk scores.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                    . 27, 269\u2013275.\n                  <\/jats:p>","DOI":"10.1089\/ars.2016.6970","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T12:01:41Z","timestamp":1481716901000},"page":"269-275","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Could NLRP3\u2013Inflammasome Be a Cardiovascular Risk Biomarker in Acute Myocardial Infarction Patients?"],"prefix":"10.1177","volume":"27","author":[{"given":"Pedro","family":"Bull\u00f3n","sequence":"first","affiliation":[{"name":"University of Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Cano-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Facultad de Psicolog\u00eda Universidad de Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edsabet","family":"Alcocer-G\u00f3mez","sequence":"additional","affiliation":[{"name":"University of Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Varela-L\u00f3pez","sequence":"additional","affiliation":[{"name":"University of Granada","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Roman-Malo","sequence":"additional","affiliation":[{"name":"University of Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael J.","family":"Ruiz-Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Heart Center","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Quiles","sequence":"additional","affiliation":[{"name":"University of Granada","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Navarro-Pando","sequence":"additional","affiliation":[{"name":"Instituto para el Estudio de la Biolog\u00eda de la Reproducci\u00f3n Humana (INEBIR)","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Universidad Europea del Atlantico","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Ruiz-Cabello","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Jim\u00e9nez-Borreguero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital La Princesa, Madrid, Spain."},{"name":"National Center for Cardiovascular Research (CNIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario D.","family":"Cordero","sequence":"additional","affiliation":[{"name":"University of Sevilla","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-015-0723-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.033"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv126"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6319"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303791"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6864"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306656"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2015.05.008"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2016.6970","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2016.6970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2016.6970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:40Z","timestamp":1777377280000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2016.6970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1089\/ars.2016.6970"],"URL":"https:\/\/doi.org\/10.1089\/ars.2016.6970","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}