{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:30:39Z","timestamp":1791289839016,"version":"4.3.0"},"reference-count":71,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      plays an important role in sepsis, pneumonia, and wound infections. Acid sphingomyelinase (Asm)-deficient mice are highly susceptible to pulmonary\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      infections. Here, we investigated the role of CD44 as a molecule that mediates important aspects of the infection of macrophages with\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We showed that CD44 activation by\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      stimulated Asm via the formation of reactive oxygen species, resulting in ceramide release, clustering of CD44 in ceramide-enriched membrane platforms, CD44\/Asm-dependent activation of Rho family GTPases, translocation of phospho-ezrin\/radixin\/moesin to the plasma-membrane, and a rapid rearrangement of the actin cytoskeleton with cortical actin polymerization. Genetic deficiency of CD44 or Asm abrogated these signaling events and thereby reduced internalization of\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      into macrophages by 60\u201380%. Asm-deficient macrophages also exhibited reduced fusion of phagosomes with lysosomes, which prevented intracellular killing of\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      in macrophages and thereby allowed internalized\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      to replicate and cause severe pneumonia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>\n                      The CD44-Asm-ceramide system plays an important role in the infection of macrophages with\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      28, 916\u2013934.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2017.6994","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:21:44Z","timestamp":1501114904000},"page":"916-934","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Regulation of\n                    <i>Staphylococcus aureus<\/i>\n                    Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase"],"prefix":"10.1177","volume":"28","author":[{"given":"Cao","family":"Li","sequence":"first","affiliation":[{"name":"University Hospital","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Wu","sequence":"additional","affiliation":[{"name":"University 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