{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:51:32Z","timestamp":1789663892925,"version":"4.0.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants & Redox Signaling"],"published-print":{"date-parts":[[2017,12]]},"abstract":"\n The C242T polymorphism of\n CYBA<\/jats:italic>\n (cytochrome B-245 alpha chain), the gene encoding the p22phox subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, has been linked to several conditions in which oxidative stress plays a pathogenic role. We investigated in a cohort of 451 preterm infants [gestational age (GA) \u226430 weeks] the association of the polymorphism with the risk of developing neonatal respiratory distress syndrome (RDS), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, patent ductus arteriosus, or intraventricular hemorrhage. We observed a significant association of the TT\/CT genotype with RDS [odds ratio (OR) 2.34, 95% confidence interval (95% CI) 1.28\u20133.90], ROP (OR 1.72, 95% CI 1.05\u20132.80), and BPD (OR 1.60, 95% CI 1.05\u20132.43). When this dominant model was adjusted to account for GA, birth weight, and sex, it remained significant for the three outcomes. This study is the first to address the association of a polymorphism related to the NADPH family with oxidative stress-related complications of prematurity. Since p22phox is essential for reactive oxygen species production by NADPH oxidase, we hypothesize that genetic variations in the protein may lead to differences in susceptibility to oxidative stress-induced damage in preterm infants.\n Antioxid. Redox Signal.<\/jats:italic>\n 27, 1432\u20131438.\n <\/jats:p>","DOI":"10.1089\/ars.2017.7042","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T10:24:12Z","timestamp":1491301452000},"page":"1432-1438","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Is the C242T Polymorphism of the\n CYBA<\/i>\n Gene Linked with Oxidative Stress-Associated Complications of Prematurity?"],"prefix":"10.1177","volume":"27","author":[{"given":"Maurice J.","family":"Huizing","sequence":"first","affiliation":[{"name":"Maastricht University Medical Center (MUMC+)","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob M.","family":"Moonen","sequence":"additional","affiliation":[{"name":"Zuyderland Medical Center Heerlen","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema E.","family":"Gonz\u00e1lez-Luis","sequence":"additional","affiliation":[{"name":"Hospital Universitario Materno-Infantil de Canarias","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Mosca","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ximo","family":"Vento","sequence":"additional","affiliation":[{"name":"University and Polytechnic Hospital La Fe","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Villamor","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center (MUMC+)","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,12,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5814"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21029"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.09.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.692787"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4189"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36999"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070130"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087586"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5790"}],"container-title":["Antioxidants & Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2017.7042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2017.7042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2017.7042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:34Z","timestamp":1777377274000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2017.7042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":9,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1089\/ars.2017.7042"],"URL":"https:\/\/doi.org\/10.1089\/ars.2017.7042","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}