{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:36:26Z","timestamp":1778934986421,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants & Redox Signaling"],"published-print":{"date-parts":[[2018,9]]},"abstract":"\n Haptoglobin's (\n Hp<\/jats:italic>\n ) main role is to bind free hemoglobin (Hb), reducing its oxidative potential. The\n Hp<\/jats:italic>\n \u2013Hb complex formed is cleared from the circulation by macrophage receptor CD163. In diabetes, impaired\n Hp<\/jats:italic>\n 2-2\u2013Hb CD163 clearance and abnormal glomerular permeability allow the large\n Hp<\/jats:italic>\n 2-2\u2013Hb complex to cross the barrier, where its redox active iron leads to cellular toxicity. Although\n Hp<\/jats:italic>\n 2-2 predicts renal function decline, whether renal iron deposition differs by\n Hp<\/jats:italic>\n is unknown. We used renal quantitative T2* magnetic resonance imaging to estimate iron level in the cortex and medullar of type 1 diabetes (T1D) adults [15\n Hp<\/jats:italic>\n 1-1 and 15\n Hp<\/jats:italic>\n 2-2 carriers of similar age (53 years), duration (45 years), and gender]. Total kidney iron level was estimated as the sum of the cortex and medullar iron. Albuminuria was defined as urinary albumin to creatinine ratio >30\u2009mg\/g in two of three samples. Total kidney iron did not differ by gender or\n Hp<\/jats:italic>\n but was higher in those with albuminuria (\n p<\/jats:italic>\n \u2009=\u20090.05), an association confined to\n Hp<\/jats:italic>\n 2-2 carriers (\n p<\/jats:italic>\n \u2009=\u20090.04\n vs. p<\/jats:italic>\n \u2009=\u20090.51 in\n Hp<\/jats:italic>\n 1-1). These data lead to the hypothesis that kidney iron deposition is increased among\n Hp<\/jats:italic>\n 2-2 carriers with albuminuria in T1D.\n Antioxid. Redox Signal<\/jats:italic>\n . 29, 735\u2013741.\n <\/jats:p>","DOI":"10.1089\/ars.2017.7444","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T23:50:18Z","timestamp":1515023418000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Is Magnetic Resonance Imaging Detection of Kidney Iron Deposition Increased in Haptoglobin 2-2 Genotype Carriers with Type 1 Diabetes?A version of the abstract was previously presented at the 77th Scientific Sessions of the American Diabetes Association, San Diego, CA, June 9\u201313, 2017."],"prefix":"10.1177","volume":"29","author":[{"given":"Tina","family":"Costacou","sequence":"first","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor J.","family":"Orchard","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Hong","family":"Moon","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyongtae T.","family":"Bae","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Fried","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"Veterans Pittsburgh Health Care System of Pittsburgh"},{"name":"University of Pittsburgh School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhobert W.","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.015"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0874"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0770-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1118"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132423"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/42.10.1589"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-s251"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90655.2008"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0256"}],"container-title":["Antioxidants & Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2017.7444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2017.7444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2017.7444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:25Z","timestamp":1777377325000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2017.7444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1089\/ars.2017.7444"],"URL":"https:\/\/doi.org\/10.1089\/ars.2017.7444","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}