{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:24:00Z","timestamp":1791300240326,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    Epidemiological, preclinical and interventional clinical studies have demonstrated that environmental stressors are associated with health problems, namely cardiovascular diseases. According to estimations of the World Health Organization (WHO), environmental risk factors account for an appreciable part of global deaths and life years spent with disability. This Forum addresses the impact of the environmental risk factors such as traffic noise exposure, air pollution by particulate matter (PM), mental stress\/loneliness, and the life style risk factor (water-pipe) smoking on health and disease with focus on the cardiovascular system. We will critically discuss the use of observatory\/modifiable biomarkers of oxidative stress and inflammation in environmental research on the aforementioned risk factors highlighting the need of exposome studies. Another focus will be on the epigenetic regulation\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    microRNAs in environmental stress upon exposure to noise and toxins\/heavy metals as well as mental stress conditions, providing mechanistic insights into the modulation of microRNA signaling by oxidative stress, and vice versa the contribution of microRNAs to oxidative stress conditions. We will also provide an in-depth overview on the mechanistic pathways that lead to health problems (\n                    <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                    , cardiovascular diseases) in response to environmental psychosocial stress, air pollution exposure in the form of ambient PM and diesel exhaust, traffic noise exposure, and the life style drug (water-pipe) smoking. Almost all stressors share the activation of the hypothalamic-pituitary-adrenocortical axis and of the sympathetic nervous system with subsequent onset of inflammation and oxidative stress, defining the here proposed therapeutic (antioxidant and exercise) strategies.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    28, 735\u2013740.\n                  <\/jats:p>","DOI":"10.1089\/ars.2017.7488","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:24:49Z","timestamp":1514334289000},"page":"735-740","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":144,"title":["Environmental Stressors and Their Impact on Health and Disease with Focus on Oxidative Stress"],"prefix":"10.1177","volume":"28","author":[{"given":"Thomas","family":"M\u00fcnzel","sequence":"first","affiliation":[{"name":"Johannes Gutenberg University Medical Center","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Daiber","sequence":"additional","affiliation":[{"name":"Johannes Gutenberg University Medical Center","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","unstructured":"Ghezzi P Floridi L Boraschi D Cuadrado A Manda G Levic S D'Acquisto F Hamilton A Athersuch TJ and Selley L. Oxidative stress and inflammation induced by environmental and psychological stressors: a biomarker perspective. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7147.","DOI":"10.1089\/ars.2017.7147"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","unstructured":"Golbidi S Li H and Laher I. Oxidative stress: a unifying mechanism for cell damage induced by noise (water-pipe) smoking and emotional stress. Therapeutic strategies targeting redox imbalance. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7257.","DOI":"10.1089\/ars.2017.7257"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","unstructured":"Meyer T and Wirtz PH. Mechanisms of mitochondrial redox signaling in psychosocial stress-responsive systems: new insights into an old story. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7186.","DOI":"10.1089\/ars.2017.7186"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","unstructured":"Miguel V Cui JY Daimiel L Espinosa-Diez C Fernandez-Hernando C Kavanagh TJ and Lamas S. The role of microRNAs in environmental risk factors noise-induced hearing loss and mental stress. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7175.","DOI":"10.1089\/ars.2017.7175"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","unstructured":"M\u00fcnzel T Sorensen M Schmidt F Schmidt E Steven S Kr\u00f6ller-Sch\u00f6n S and Daiber A. The impact of environmental noise exposure on oxidative stress and cardiovascular risk. Antioxid Redox Signal 00: 00\u201300 2018. This issue. DOI: 10.1089\/ars.2017.7118.","DOI":"10.1089\/ars.2017.7118"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","unstructured":"Rao X Zhong J Brook RD and Rajagopalan S. Effect of particulate matter air pollution on cardiovascular oxidative stress pathways. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7394.","DOI":"10.1089\/ars.2017.7394"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","unstructured":"Wilson SJ Miller MR and Newby DE. Effects of diesel exhaust on cardiovascular function and oxidative stress. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7174.","DOI":"10.1089\/ars.2017.7174"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","unstructured":"Xia N and Li H. Loneliness social isolation and cardiovascular health. Antioxid Redox Signal 00: 00\u201300 2017. This issue. DOI: 10.1089\/ars.2017.7312.","DOI":"10.1089\/ars.2017.7312"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2017.7488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2017.7488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2017.7488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:06Z","timestamp":1777377306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2017.7488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1089\/ars.2017.7488"],"URL":"https:\/\/doi.org\/10.1089\/ars.2017.7488","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}