{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:53:39Z","timestamp":1788054819002,"version":"build-2784847793"},"reference-count":72,"publisher":"SAGE Publications","issue":"16","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Astrocytes have been revealed as a controller of synaptic plasticity and memory\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) and polysulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S\n                      <jats:sub>n<\/jats:sub>\n                      ), regulated the availability of\n                      <jats:sc>d<\/jats:sc>\n                      -serine, which is a well-known gliotransmitter that is involved in synaptic plasticity. An interesting question is whether RSS, which are small molecules, can function as direct gliotransmitters to integrate astrocyte-neuron interactions throughout the memory process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found that hippocampal RSS level increased significantly in response to learning. We further demonstrated that the activity-triggered RSS signal controlled memory formation by using pharmacological and genetic approaches. The RSS-supporting memory was primarily conferred by enzymes that were mainly located in astrocytes, including cystathionine \u03b2-synthase (CBS) and mercaptopyruvate sulfurtransferase (3-MST), and the memory-promoting effects were mostly dependent on sulfration of the NR2A subunit of N-methyl-\n                      <jats:sc>d<\/jats:sc>\n                      -aspartate subtype glutamate receptors (NMDARs). Further, RSS were demonstrated to buffer the strong inhibitory effect of synaptically released zinc on NR2A-containing NMDARs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>These results suggest that glial-derived RSS signals can serve as direct gliotransmitters that regulate memory formation through the redox modulation of postsynaptic receptors; this conclusion will enrich the gliotransmission hypothesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2018.7503","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T07:15:01Z","timestamp":1536218101000},"page":"1880-1899","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Reactive Sulfur Species Emerge as Gliotransmitters to Support Memory\n                    <i>via<\/i>\n                    Sulfuration-Dependent Gating of NR2A-Containing N-Methyl-\n                    <scp>d<\/scp>\n                    -Aspartate Subtype Glutamate Receptor Function"],"prefix":"10.1177","volume":"30","author":[{"given":"Han","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Qian","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Long","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."},{"name":"Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, China."},{"name":"The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China."},{"name":"Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China."},{"name":"The Collaborative-Innovation Center for Brain Science, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Guo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."},{"name":"Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, China."},{"name":"The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China."},{"name":"Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China."},{"name":"The Collaborative-Innovation Center for Brain Science, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1184821"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)75684-6"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503348112"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja404004v"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(96)00136-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-02-00392.2001"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0422-2"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.09.014"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3724fje"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.143941"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81070-3"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06580.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.11.021"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5041"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08673"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6737"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21017"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1258-06.2006"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.09.007"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512927200"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.026"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226415"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14774"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607131103"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.06.001"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6936"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12585"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00034"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05502.x"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666150713102326"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.11.002"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-008-9289-7"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12228"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21822"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12698"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2015.03.003"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240242"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050286"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.01.056"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.27.16230"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605931200"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.036"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1018"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4401"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.051"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/369744a0"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3391"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201303757"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00466.2012"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3836-12.2013"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.021"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201200331"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.039"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00087"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2371"},{"key":"e_1_3_4_59_2","unstructured":"This reference has been deleted."},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2253"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5779-12.2013"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.003"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2623"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81149-6"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001631"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01143.x"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.09.007"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-202"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322912111"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2431073100"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b00172"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8360738"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067322"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2018.7503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2018.7503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2018.7503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:35Z","timestamp":1777377335000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2018.7503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":72,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1089\/ars.2018.7503"],"URL":"https:\/\/doi.org\/10.1089\/ars.2018.7503","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]}}}