{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:19:25Z","timestamp":1780057165967,"version":"3.54.0"},"reference-count":95,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Dr. Hideo Kimura is recognized as a redox pioneer because he has published an article in the field of antioxidant and redox biology that has been cited &gt;1000 times, and 29 articles that have been cited &gt;100 times. Since the first description of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) as a toxic gas 300 years ago, most studies have been devoted to its toxicity. In 1996, Dr. Kimura demonstrated a physiological role of H\n                    <jats:sub>2<\/jats:sub>\n                    S as a mediator of cognitive function and cystathionine \u03b2-synthase as an H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing enzyme. In the following year, he showed H\n                    <jats:sub>2<\/jats:sub>\n                    S as a vascular smooth muscle relaxant in synergy with nitric oxide and its production by cystathionine \u03b3-lyase in vasculature. Subsequently he reported the cytoprotective effect of H\n                    <jats:sub>2<\/jats:sub>\n                    S on neurons against oxidative stress. Since then, studies on H\n                    <jats:sub>2<\/jats:sub>\n                    S have unveiled numerous physiological roles such as the regulation of inflammation, cell growth, oxygen sensing, and senescence. He also discovered polysulfides (H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    ), which have a higher number of sulfur atoms than H\n                    <jats:sub>2<\/jats:sub>\n                    S and are one of the active forms of H\n                    <jats:sub>2<\/jats:sub>\n                    S, as potent signaling molecules produced by 3-mercaptopyruvate sulfurtransferase. H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    regulate ion channels and transcription factors to upregulate antioxidant genes, tumor suppressors, and protein kinases to, in turn, regulate blood pressure. These findings led to the re-evaluation of other persulfurated molecules such as cysteine persulfide and glutathione persulfide. Dr. Kimura is a pioneer of studies on H\n                    <jats:sub>2<\/jats:sub>\n                    S and H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    as signaling molecules.\n                  <\/jats:p>","DOI":"10.1089\/ars.2018.7618","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T10:55:45Z","timestamp":1537440945000},"page":"1699-1708","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Redox Pioneer: Professor Hideo Kimura"],"prefix":"10.1177","volume":"30","author":[{"given":"David","family":"Lefer","sequence":"first","affiliation":[{"name":"Louisiana State University Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90310-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01311-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3203"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(71)90105-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053319"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199919"},{"key":"e_1_3_2_9_2","first-page":"253","article-title":"The mechanism of desulphhydration of cysteine","volume":"24","author":"Cavallini D","year":"1962","unstructured":"Cavallini D, , Mondovi B, , De Marco C, , and Scioscia-Santoro A. 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