{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:06:28Z","timestamp":1780380388620,"version":"3.54.1"},"reference-count":73,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      In this original research communication, we assess the impact of shifting the window of glial\n                      <jats:italic toggle=\"yes\">HMOX1<\/jats:italic>\n                      overexpression in mice from early-to-midlife to mid-to-late life, resulting in two disparate conditions modeling schizophrenia (SCZ) and Parkinson's disease (PD). Mesolimbic hyperdopaminergia is a widely accepted feature of SCZ, while nigrostriatal hypodopaminergia is the\n                      <jats:italic toggle=\"yes\">sine qua non<\/jats:italic>\n                      of idiopathic PD. Although the advent of parkinsonian features in SCZ patients after treatment with antidopaminergic agents is intuitive, subtle features of parkinsonism commonly observed in young, drug-na\u00efve schizophrenics are not. Similarly, emergent psychosis in PD subjects receiving levodopa replacement is not unusual, whereas spontaneous hallucinosis in nonmedicated persons with idiopathic PD is enigmatic. Investigations using\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/GFAP.HMOX1\">GFAP.HMOX1<\/jats:uri>\n                      mice may shed light on these clinical paradoxes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Astroglial heme oxygenase-1 (HO-1) overexpression in mice throughout embryogenesis until 6 or 12 months of age resulted in hyperdopaminergia, hyperkinesia\/stereotypy ameliorated with clozapine, deficient prepulse inhibition of the acoustic startle response, reduced preference for social novelty, impaired nest building, and cognitive dysfunction reminiscent of SCZ. On the contrary, astroglial HO-1 overexpression between 8.5 and 19 months of age yielded a PD-like behavioral phenotype with hypodopaminergia, altered gait, locomotor incoordination, and reduced olfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>\n                      We conjecture that region-specific disparities in the susceptibility of dopaminergic and other circuitry to the trophic and degenerative influences of glial\n                      <jats:italic toggle=\"yes\">HMOX1<\/jats:italic>\n                      induction may permit the concomitant expression of mixed SCZ and PD traits within affected individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Elucidation of these converging mechanisms may (i) help better understand disease pathogenesis and (ii) identify HO-1 as a potential therapeutic target in neurodevelopmental and neurodegenerative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2019.7937","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T02:49:08Z","timestamp":1576637348000},"page":"1259-1272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Strategic Timing of Glial\n                    <i>HMOX1<\/i>\n                    Expression Results in Either Schizophrenia-Like or Parkinsonian Behavior in Mice"],"prefix":"10.1177","volume":"32","author":[{"given":"Ayda","family":"Tavitian","sequence":"first","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Cressatti","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana Z.","family":"Turk","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Galindez","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Smart","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Liberman","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyman M.","family":"Schipper","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada."},{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000243"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00298"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1237376"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.028"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80100-0"},{"key":"e_1_3_4_7_2","first-page":"678","article-title":"[Reversible parkinsonism in the course of largactil therapy of vomiting in pregnancy]","volume":"131","author":"Bergouignan M","year":"1954","unstructured":"Bergouignan M and Regnier. [Reversible parkinsonism in the course of largactil therapy of vomiting in pregnancy]. J Med Bord, 131: 678\u2013679, 1954.","journal-title":"J Med Bord"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(87)90009-6"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90576-5"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.09.003"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3074"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.9.1343"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00729-9"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813361106"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.03.008"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008686"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23645"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.170"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0216-5"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.200"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7214"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi239"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12927"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10713"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.03.011"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011838"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/15622970902806124"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23609"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0234-1"},{"key":"e_1_3_4_32_2","first-page":"e51804","article-title":"Olfactory assays for mouse models of neurodegenerative disease","volume":"90","author":"Lehmkuhl AM","year":"2014","unstructured":"Lehmkuhl AM, , Dirr ER, , and Fleming SM. Olfactory assays for mouse models of neurodegenerative disease. J Vis Exp, 90: e51804, 2014.","journal-title":"J Vis Exp"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.079426"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01261.x"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(96)02211-X"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00354.x"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033354"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n1110"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2004.11.002"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014472"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-013-0472-6"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-6357(99)00053-4"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2016.62.14.2"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.008"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001511"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00392.x"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.01.012"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.2478\/bjmg-2014-0070"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00073"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2004.02.001"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033339"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.09.015"},{"key":"e_1_3_4_53_2","first-page":"267","volume-title":"Mitochondrial Ubiquinone (Coenzyme Q): Biochemical, Functional, Medical, and Therapeutic Aspects in Human Health and Disease","author":"Schipper HM.","year":"2001","unstructured":"Schipper HM. Mitochondrial iron deposition in aging astroglia: mechanisms and disease implications. In: Mitochondrial Ubiquinone (Coenzyme Q): Biochemical, Functional, Medical, and Therapeutic Aspects in Human Health and Disease, edited by Ebadi M, , Marwah J, , and Chopra RK, , Scottsdale AZ: Prominent Press, 2001, pp. 267\u2013280."},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0721802.x"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6752"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.06.008"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200101)16:1<114::AID-MDS1004>3.0.CO;2-2"},{"key":"e_1_3_4_58_2","first-page":"282","article-title":"Psychosis in neurodegenerative disease","volume":"1","author":"Snow RE","year":"1996","unstructured":"Snow RE, and Arnold SE. Psychosis in neurodegenerative disease. Semin Clin Neuropsychiatry, 1: 282\u2013293, 1996.","journal-title":"Semin Clin Neuropsychiatry"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21367"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.06.017"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27328"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.05.025"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6469-11.2012"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07914.x"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23356"},{"key":"e_1_3_4_66_2","first-page":"737","article-title":"[Extrapyramidal and diencephalic syndrome in the course of largactil and serpasil treatments]","volume":"112","author":"Steck H","year":"1954","unstructured":"Steck H. [Extrapyramidal and diencephalic syndrome in the course of largactil and serpasil treatments]. Ann Med Psychol (Paris), 112: 737\u2013744, 1954.","journal-title":"Ann Med Psychol (Paris)"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.38"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858418824072"},{"key":"e_1_3_4_69_2","first-page":"52329","article-title":"Environmental modulations of the number of midbrain dopamine neurons in adult mice","volume":"95","author":"Tomas D","year":"2015","unstructured":"Tomas D, , Prijanto AH, , Burrows EL, , Hannan AJ, , Horne MK, , and Aumann TD. Environmental modulations of the number of midbrain dopamine neurons in adult mice. J Vis Exp, 95: 52329, 2015.","journal-title":"J Vis Exp"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28377"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.06.007"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199702100-00037"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.04.009"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.07.046"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2019.7937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2019.7937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2019.7937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:46Z","timestamp":1777377226000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2019.7937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":73,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1089\/ars.2019.7937"],"URL":"https:\/\/doi.org\/10.1089\/ars.2019.7937","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]}}}