{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:47:34Z","timestamp":1790862454216,"version":"4.1.0"},"reference-count":8,"publisher":"SAGE Publications","issue":"17","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>\n                    This Forum issue \u201cHeme Oxygenase\u201d (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual role that HO-1 displays in cells and tissues, and address the molecular and cellular mechanisms through which HO-1 participates in the pathophysiology of the metabolic syndrome, obesity, cancer, and neurodegenerative, neurodevelopmental, and inflammatory bowel diseases. Indeed, one of the reviews thoroughly describes evidence of the anti-inflammatory properties of HO-1 in gut homeostasis, with potential to attenuate inflammatory bowel diseases. Three other reviews show the mostly beneficial effect of HO-1 expression in the attenuation of metabolic syndrome, obesity, cardiovascular disease, and diabetic cardiomyopathy. Contrariwise, one of the original articles show the overexpression of HO-1 in astroglia, models neurodegenerative (Parkinson-like) or neurodevelopmental (Schizophrenia-like) behaviors in mice, depending on the timing of expression of HO-1 during lifespan. The other original research communication demonstrates the role of HO-1 on the tropism of prostate cancer cells to bone, thus showing the involvement of this protein in the communication between bone and cancer cells. Finally, the Forum issue includes a review that elaborates on the classic and ultimate knowledge of HO-1 transcriptional regulation as well as the mechanisms of alternative splicing and post-transcriptional regulation of Hmox1 gene expression that have been little explored.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    32, 1239\u20131242.\n                  <\/jats:p>","DOI":"10.1089\/ars.2020.8065","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T02:16:42Z","timestamp":1583720202000},"page":"1239-1242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":85,"title":["Heme-Oxygenase-1"],"prefix":"10.1177","volume":"32","author":[{"given":"Mar\u00eda M.","family":"Facchinetti","sequence":"first","affiliation":[{"name":"Dpto. de Biolog\u00eda, Bioqu\u00edmica y Farmacia (UNS), Laboratorio de Biolog\u00eda del C\u00e1ncer, Instituto de Investigaciones Bioqu\u00edmicas de Bah\u00eda Blanca (INIBIBB), Universidad Nacional del Sur (UNS)-CONICET, Bah\u00eda Blanca, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Heme oxygenase-1 is a pivotal modulator of bone turn over and remodeling: molecular implications for prostate cancer bone metastasis","volume":"32","author":"Anselmino N","unstructured":"Anselmino N, , Starbuck M, , Labanca E, , Cotignola J, , Navone N, , Gueron G, , and Vazquez ES. Heme oxygenase-1 is a pivotal modulator of bone turn over and remodeling: molecular implications for prostate cancer bone metastasis. Antioxid Redox Signal, 32: 1243\u20131258, 2020.","journal-title":"Antioxid Redox Signal"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7970"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.108073"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7956"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7991"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7954"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7937"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7989"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2020.8065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2020.8065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2020.8065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:47Z","timestamp":1777377227000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2020.8065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":8,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1089\/ars.2020.8065"],"URL":"https:\/\/doi.org\/10.1089\/ars.2020.8065","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]}}}