{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:48:00Z","timestamp":1777434480258,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>\n                    This Forum was conceived as a means to usher in the age of H\n                    <jats:sub>2<\/jats:sub>\n                    S-based therapeutics and H\n                    <jats:sub>2<\/jats:sub>\n                    S-aided regenerative medicine. H\n                    <jats:sub>2<\/jats:sub>\n                    S prodrugs\u2014now in advanced stages of pharmaceutical development\u2014will soon be available for treatment of a remarkably wide range of serious health conditions with minimal side effects\/adverse reactions. Also foreseeable is the advent of a time in which the \u201cone drug-one target\u201d paradigm will be phased out, whereas multitargeted H\n                    <jats:sub>2<\/jats:sub>\n                    S prodrugs find expanding roles in the treatment of highly complex disease states\u2014such paradigm change will prevent polypharmacy and bring about truly disease-modifying outcomes. In the seven articles comprising Parts A and B of this Forum (2\u20134, 6\u20139), international experts survey remarkably diverse landscapes of small and large H\n                    <jats:sub>2<\/jats:sub>\n                    S donor molecules, H\n                    <jats:sub>2<\/jats:sub>\n                    S release profiles and mechanisms, pharmacophores\/metabolic routes, and potential therapeutic or prophylactic indications. Donors of related sulfur species, such as persufides, SO\n                    <jats:sub>2<\/jats:sub>\n                    , carbon oxysulfide (COS), and carbon disulfide, are examined as well. This Editorial highlights a few of the insights shared by the 32 Forum contributors and includes a proposed classification of H\n                    <jats:sub>2<\/jats:sub>\n                    S\/COS prodrugs that is intended to aid in the systematization of this burgeoning field.\n                  <\/jats:p>","DOI":"10.1089\/ars.2020.8078","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T04:50:31Z","timestamp":1595307031000},"page":"999-1002","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["On H\n                    <sub>2<\/sub>\n                    S Prodrugs"],"prefix":"10.1177","volume":"33","author":[{"given":"Gabriel","family":"Gojon","sequence":"first","affiliation":[{"name":"Sulfagenix, Inc., Tucson, Arizona, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14394"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7884"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8060"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7864"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2018.08.012"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7841"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7888"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7896"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7880"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2020.8078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2020.8078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2020.8078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:01Z","timestamp":1777377241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2020.8078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":9,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1089\/ars.2020.8078"],"URL":"https:\/\/doi.org\/10.1089\/ars.2020.8078","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]}}}