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No specific therapies for other phenotypes (muscular dystrophy, male infertility, hearing loss, neurodegeneration) exist as yet, but their severity often requires supportive medical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      These disorders provide unique insights into the role of selenoproteins in humans. The long-term consequences of reduced cellular antioxidant capacity remain unknown, and future surveillance of patients may reveal time-dependent phenotypes (\n                      <jats:italic toggle=\"yes\">e.g<\/jats:italic>\n                      ., neoplasia, aging) or consequences of deficiency of selenoproteins whose function remains to be elucidated. The role of antioxidant therapies requires evaluation.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      33, 481\u2013497.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2020.8097","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T04:50:24Z","timestamp":1587012624000},"page":"481-497","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency"],"prefix":"10.1177","volume":"33","author":[{"given":"Erik","family":"Schoenmakers","sequence":"first","affiliation":[{"name":"Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.09.007"},{"key":"e_1_3_2_3_2","first-page":"547","article-title":"A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis","volume":"140","author":"Ahmed MY","year":"2017","unstructured":"Ahmed MY, , Al-Khayat A, , Al-Murshedi F, , Al-Futaisi A, , Chioza BA, , Pedro Fernandez-Murray J, , Self JE, , Salter CG, , Harlalka GV, , Rawlins LE, , Al-Zuhaibi S, , Al-Azri F, , Al-Rashdi F, , Cazenave-Gassiot A, , Wenk MR, , Al-Salmi F, , Patton MA, , Silver DL, , Baple EL, , McMaster CR, , and Crosby AH. 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