{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:08:42Z","timestamp":1783692522539,"version":"3.55.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"16-18","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Peripubertal endocrine disruption has immediate and lifelong consequences on health, cognition, and lifespan. Disruption comes from dietary, environmental, and pharmaceutical sources. The plasticizer Bisphenol A (BPA) is one such endocrine disrupting chemical. However, it is unclear whether peripubertal BPA exposure incites long-lasting physiological, neuro-cognitive, and\/or longevity-related metabolic impairments. Catabolism of cysteine\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      transsulfuration enzymes produces hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S), a redox-modulating gasotransmitter causative to endocrine and metabolic homeostasis and improved cognitive function with age. As thyroid hormone (TH) regulates hepatic H\n                      <jats:sub>2<\/jats:sub>\n                      S production and BPA is a TH receptor antagonist, we hypothesized that BPA exposure during peripubertal development impairs metabolic and neuro-cognitive\/behavioral endpoints in aged mice, in part, due to altered peripheral and\/or localized H\n                      <jats:sub>2<\/jats:sub>\n                      S production and redox status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      To test this, male C57BL\/6J mice at 5 weeks of age were orally exposed daily for 5 weeks to 250\u2009\u03bcg BPA\/kg, defined as low dose group (LD BPA), or 250\u2009mg BPA\/kg, defined as high dose group (HD BPA). Both LD and HD BPA exposure decreased lean mass and increased fat mass accompanied by decreased serum total TH at advanced ages. In addition, LD BPA had an anxiogenic effect whereas HD BPA caused cognitive deficits. Notably, HD BPA disrupted tissue-specific H\n                      <jats:sub>2<\/jats:sub>\n                      S production capacities and\/or protein persulfidation, with the former negatively correlated with memory deficits and oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>\n                      These findings provide a potential mechanism of action for acute and long-term health impacts of BPA-induced peripubertal endocrine disruption and bolster the need for improved monitoring and limitation of adolescent BPA exposure.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      36, 1246\u20131267.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2020.8226","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:06:57Z","timestamp":1627391217000},"page":"1246-1267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Peripubertal Bisphenol A Exposure Imparts Detrimental Age-Related Changes in Body Composition, Cognition, and Hydrogen Sulfide Production Capacities"],"prefix":"10.1177","volume":"36","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko O.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmin","family":"Bithi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1926-7939","authenticated-orcid":false,"given":"Christopher","family":"Hine","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1952"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr560"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.07.017"},{"key":"e_1_3_6_5_2","first-page":"1","article-title":"Association between bisphenol A exposure and risk of all-cause and cause-specific mortality in US adults","volume":"3","author":"Bao W","year":"2020","unstructured":"Bao W, , Liu B, , Rong S, , Dai SY, , Trasande L, , and Lehmler H. 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