{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:29:46Z","timestamp":1792096186857,"version":"4.4.0"},"reference-count":81,"publisher":"SAGE Publications","issue":"4-6","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S), an important regulator of physiology and health, helps resolve inflammation and promotes tissue repair in the gastrointestinal tract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Gut microbiota live as a multispecies biofilm in close interaction with the upper mucus layer lining the epithelium. The relative abundance, spatial organization, and function of these microorganisms affect a broad range of health outcomes. This article provides a state-of-the-art review of our understanding of the cross talk between H\n                      <jats:sub>2<\/jats:sub>\n                      S, the gut microbiota, and health. H\n                      <jats:sub>2<\/jats:sub>\n                      S can have toxic or therapeutic effects, depending on its concentration and source. When produced at excessive concentrations by local microbiota, H\n                      <jats:sub>2<\/jats:sub>\n                      S may cause mucus disruption and inflammation and contribute to development of cancer. In contrast, low levels of endogenous or exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S directly stabilize mucus layers, prevent fragmentation and adherence of the microbiota biofilm to the epithelium, inhibit the release of invasive pathobionts, and help resolve inflammation and tissue injury. Although scarce, research findings suggest that dietary H\n                      <jats:sub>2<\/jats:sub>\n                      S obtained from plants or ingestion of the H\n                      <jats:sub>2<\/jats:sub>\n                      S precursor, L-cysteine, may also modulate the abundance and function of microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      A critical issue is the lack of understanding of the metagenomic, transcriptomic, and proteomic alterations that characterize the interactions between H\n                      <jats:sub>2<\/jats:sub>\n                      S and gut microbiota to shape health outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      The ambivalent roles of H\n                      <jats:sub>2<\/jats:sub>\n                      S in the gut offer a fertile ground for research on such critical issues. The findings will improve our understanding of how H\n                      <jats:sub>2<\/jats:sub>\n                      S modulates the microbiota to affect body function and will help identify novel therapeutic strategies.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                      . 36, 211\u2013219.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0004","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:24:51Z","timestamp":1615422291000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":144,"title":["Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy"],"prefix":"10.1177","volume":"36","author":[{"given":"Andre G.","family":"Buret","sequence":"first","affiliation":[{"name":"Host\u2013Parasite Interactions Program, Inflammation Research Network, Biological Sciences, University of Calgary, Calgary, Canada."},{"name":"Antibe Therapeutics, Inc., Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Allain","sequence":"additional","affiliation":[{"name":"Host\u2013Parasite Interactions Program, Inflammation Research Network, Biological Sciences, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Motta","sequence":"additional","affiliation":[{"name":"Institute of Digestive Health Research, IRSD, INSERM U1220, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Host\u2013Parasite Interactions Program, Inflammation Research Network, Biological Sciences, University of Calgary, Calgary, Canada."},{"name":"Antibe Therapeutics, Inc., Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.20546"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.10.012"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.11.010"},{"key":"e_1_3_4_6_2","first-page":"68","article-title":"Cysteine-derived hydrogen sulfide and gut health: a matter of endogenous or bacterial origin","volume":"22","author":"Blachier F","year":"2019","unstructured":"Blachier F, , Beaumont M, , and Kim E. Cysteine-derived hydrogen sulfide and gut health: a matter of endogenous or bacterial origin. Curr Opin Clin Nutr Metab Care, 22: 68\u201375, 2019.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12961"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0495-4"},{"key":"e_1_3_4_9_2","first-page":"2792","article-title":"Anaerobic degradation of the plant sugar Sulfoquinovose concomitant with hydrogen sulfide production: Escherichia coli K-12 and Desulfovibrio sp","volume":"9","author":"Burrichter A","year":"2018","unstructured":"Burrichter A, , Denger K, , Franchini P, , Huhn T, , Muller N, , Spiteller D, , and Schleheck D. Anaerobic degradation of the plant sugar Sulfoquinovose concomitant with hydrogen sulfide production: Escherichia coli K-12 and Desulfovibrio sp. strain DF1 as co-culture model. Front Microbiol, 9: 2792, 2018.","journal-title":"strain DF1 as co-culture model. Front Microbiol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.03.004"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.03.011"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7884"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/npjbiofilms.2015.5"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000183"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01372-09"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrm3946","article-title":"The health benefits of hydrogen sulphide","volume":"16","author":"Du Toit A.","year":"2015","unstructured":"Du Toit A. The health benefits of hydrogen sulphide. Nat Rev Mol Cell Biol, 16: 68, 2015.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00904-15"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101510"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115634109"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205231"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00335.2014"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4517"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18014-5"},{"key":"e_1_3_4_24_2","first-page":"67","article-title":"Prevalence of lower extremity venous disease in inflammatory bowel disease","volume":"26","author":"Gosk-Bierska I","year":"2007","unstructured":"Gosk-Bierska I, , McBane RD, , Waszczuk E, , Paradowski L, , and Wysokinski WE. Prevalence of lower extremity venous disease in inflammatory bowel disease. Int Angiol, 26: 67\u201371, 2007.","journal-title":"Int Angiol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13064"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.01.002"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2729-3"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.04.011"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-1-2"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2608"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.10.019"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030698"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8071054"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008022"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307873"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309940"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.02.007"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5312"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0036-x"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.5630"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703576114"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00060-18"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw6635"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00460-0"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy116"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11140-w"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000345"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa229"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00397-y"},{"key":"e_1_3_4_50_2","first-page":"1550","article-title":"Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene, and diallyl polysulphides","volume":"19","author":"Nakamoto M","year":"2019","unstructured":"Nakamoto M, , Kunimura K, , Suzuki J-I, , and Kodera Y. Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene, and diallyl polysulphides. Exp Ther Med, 19: 1550\u20131553, 2019.","journal-title":"Exp Ther Med"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-020-0044-8"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1740"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908047106"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21475"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18983-8"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919211117"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00970-15"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14132-y"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1339"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209855"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC00873B"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000949"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3MD00362K"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815661116"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.151"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-3-9"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.4.G727"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.266911"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21111558"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.711507"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12020"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5901"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00249.2017"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14641"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01254-20"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170311"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.1993.tb00026.x"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25500"},{"key":"e_1_3_4_80_2","first-page":"510","article-title":"Modulation of colonic hydrogen sulfide production by diet and masalazine utilizing a novel gas-profiling technology","volume":"9","author":"Yao CK","year":"2018","unstructured":"Yao CK, , Rotbart A, , Ou JZ, , Kalantar-Zadeh K, , Muir JG, , and Gibson PR. Modulation of colonic hydrogen sulfide production by diet and masalazine utilizing a novel gas-profiling technology. Gut Microbes, 9: 510\u2013522, 2018.","journal-title":"Gut Microbes"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020323"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00013.2002"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2021.0004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2021.0004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2021.0004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:52Z","timestamp":1777377292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2021.0004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":81,"journal-issue":{"issue":"4-6","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1089\/ars.2021.0004"],"URL":"https:\/\/doi.org\/10.1089\/ars.2021.0004","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}