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New, significant aspects of H\n                      <jats:sub>2<\/jats:sub>\n                      S biology in the kidney continue to emerge, underscoring the importance of this signaling molecule in kidney homeostasis, function, and disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      S signals\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      three main mechanisms, by maintaining redox balance through its antioxidant actions, by post-translational modifications of cellular proteins (S-sulfhydration), and by binding to protein metal centers. Important renal functions such as glomerular filtration, renin release, or sodium reabsorption have been shown to be regulated by H\n                      <jats:sub>2<\/jats:sub>\n                      S, using either exogenous donors or by the endogenous-producing systems.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Lower H\n                      <jats:sub>2<\/jats:sub>\n                      S levels are observed in many renal pathologies, including renal ischemia\u2013reperfusion injury and obstructive, diabetic, or hypertensive nephropathy. Unraveling the molecular targets through which H\n                      <jats:sub>2<\/jats:sub>\n                      S exerts its beneficial effects would be of great importance not only for understanding basic renal physiology, but also for identifying new pharmacological interventions for renal disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      Additional studies are needed to better understand the role of H\n                      <jats:sub>2<\/jats:sub>\n                      S in the kidney. Mapping the expression pattern of H\n                      <jats:sub>2<\/jats:sub>\n                      S-producing and -degrading enzymes in renal cells and generation of cell-specific knockout mice based on this information will be invaluable in the effort to unravel additional roles for H\n                      <jats:sub>2<\/jats:sub>\n                      S in kidney (patho)physiology. With this knowledge, novel targeted more effective therapeutic strategies for renal disease can be designed.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      36, 220\u2013243.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0014","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T12:30:17Z","timestamp":1641213017000},"page":"220-243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Hydrogen Sulfide and the Kidney: Physiological Roles, Contribution to Pathophysiology, and Therapeutic Potential"],"prefix":"10.1177","volume":"36","author":[{"given":"Maria","family":"Peleli","sequence":"first","affiliation":[{"name":"Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece."},{"name":"Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevas","family":"Zampas","sequence":"additional","affiliation":[{"name":"Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece."},{"name":"Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-5930","authenticated-orcid":false,"given":"Andreas","family":"Papapetropoulos","sequence":"additional","affiliation":[{"name":"Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece."},{"name":"Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14574"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1983-9"},{"key":"e_1_3_5_4_2","first-page":"121","article-title":"Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat","volume":"5","author":"Ahangarpour A","year":"2014","unstructured":"Ahangarpour A, , Abdollahzade Fard A, , Gharibnaseri MK, , Jalali T, , and Rashidi I. 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