{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:13:12Z","timestamp":1780089192637,"version":"3.54.0"},"reference-count":84,"publisher":"SAGE Publications","issue":"4-6","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) plays critical roles in redox biology, and its regulatory effects are tightly controlled by its cellular location and concentration. The imbalance of H\n                      <jats:sub>2<\/jats:sub>\n                      S is believed to contribute to some pathological processes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Downregulation of H\n                      <jats:sub>2<\/jats:sub>\n                      S requires chemical tools such as inhibitors of H\n                      <jats:sub>2<\/jats:sub>\n                      S-producing enzymes and H\n                      <jats:sub>2<\/jats:sub>\n                      S scavengers. Recent efforts have discovered some promising inhibitors and scavengers. These advances pave the road toward better understanding of the functions of H\n                      <jats:sub>2<\/jats:sub>\n                      S.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Precise H\n                      <jats:sub>2<\/jats:sub>\n                      S downregulation is challenging. The potency and specificity of current inhibitors are still far from ideal. H\n                      <jats:sub>2<\/jats:sub>\n                      S-producing enzymes are involved in complex sulfur metabolic pathways and ubiquitously present in biological matrices. The inhibition of these enzymes can cause unwanted side effects. H\n                      <jats:sub>2<\/jats:sub>\n                      S scavengers allow targeted H\n                      <jats:sub>2<\/jats:sub>\n                      S clearance, but their options are still limited. In addition, the scavenging process often results in biologically active by-products.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      Further development of potent and specific inhibitors for H\n                      <jats:sub>2<\/jats:sub>\n                      S-producing enzymes is needed. Scavengers that can rapidly and selectively remove H\n                      <jats:sub>2<\/jats:sub>\n                      S while generating biocompatible by-products are needed. Potential therapeutic applications of scavengers and inhibitors are worth exploring.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                      . 36, 294\u2013308.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0088","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T04:43:14Z","timestamp":1624509794000},"page":"294-308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Methods for Suppressing Hydrogen Sulfide in Biological Systems"],"prefix":"10.1177","volume":"36","author":[{"given":"Yingying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahuljeet","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"McCartney","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannie","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brock","family":"Brummett","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geat","family":"Ramush","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-2987","authenticated-orcid":false,"given":"Ming","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00799a053"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi026681n"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01311-y"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12171"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705710104"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8020048"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00313"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03456"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13459"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.904045"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01304a017"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7058"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja972654m"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2016.00102"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi970630m"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep34398"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.08.016"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00205"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.033"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115634109"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx2005234"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8030062"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964526"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep40227"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5933"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10675"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(68)90209-9"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01720"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01518K"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep20831"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b01373"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5309"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7841"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100505"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.602664"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64133-X"},{"key":"e_1_3_4_39_2","unstructured":"This reference has been deleted."},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00019"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b00087"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00493H"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5891"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.10.011"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4401"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.10.410"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.05.012"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911895116"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121692"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(77)90216-X"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(67)90217-1"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1954.02330030047004"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570100602"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.11.014"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.05.016"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029056"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.32.040192.000545"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01038a058"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201301340"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1982.tb06603.x"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805459200"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306241110"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014050"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308487110"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300841"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.09.009"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4513"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00463"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1063-2"},{"key":"e_1_3_4_73_2","first-page":"427","article-title":"I157172, a novel inhibitor of cystathionine \u03b3-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3","volume":"41","author":"Wang L","year":"2019","unstructured":"Wang L, , Shi H, , Zhang X, , Zhang X, , Liu Y, , Kang W, , Shi X, , and Wang T. I157172, a novel inhibitor of cystathionine \u03b3-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3. Oncol Rep, 41: 427\u2013436, 2019.","journal-title":"Oncol Rep"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp104144x"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06533"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00025.2008"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570070203"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13409"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905580"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0431-5"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020323"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00027"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC00968A"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc46719h"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2021.0088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2021.0088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2021.0088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:52Z","timestamp":1777377292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2021.0088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":84,"journal-issue":{"issue":"4-6","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1089\/ars.2021.0088"],"URL":"https:\/\/doi.org\/10.1089\/ars.2021.0088","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}