{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:24:01Z","timestamp":1790702641566,"version":"4.1.0"},"reference-count":200,"publisher":"SAGE Publications","issue":"1-3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                      assessment of paramagnetic and diamagnetic conversions of nitroxyl radicals based on cyclic redox mechanism can be an index of tissue redox status. The redox mechanism of nitroxyl radicals, which enables their use as a normal tissue-selective radioprotector, is seen as being attractive on planning radiation therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                      redox imaging using nitroxyl radicals as redox-sensitive contrast agents has been developed to assess tissue redox status. Chemical and biological behaviors depending on chemical structures of nitroxyl radical compounds have been understood in detail. Polymer types of nitroxyl radical contrast agents and\/or nitroxyl radical-labeled drugs were designed for approaching theranostics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>Nitroxyl radicals as magnetic resonance imaging (MRI) contrast agents have several advantages compared with those used in electron paramagnetic resonance (EPR) imaging, while support by EPR spectroscopy is important to understand information from MRI. Redox-sensitive paramagnetic contrast agents having a medicinal benefit, that is, nitroxyl-labeled drug, have been developed and proposed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      A development of suitable nitroxyl contrast agent for translational theranostic applications with high reaction specificity and low normal tissue toxicity is under progress. Nitroxyl radicals as redox-sensitive magnetic resonance contrast agents can be a useful tool to detect an abnormal tissue redox status such as disordered oxidative stress.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                      . 36, 95\u2013121.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0110","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T03:06:26Z","timestamp":1624071986000},"page":"95-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-4067","authenticated-orcid":false,"given":"Ken-ichiro","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Quantitative RedOx Sensing Group, Department of Radiation Regulatory Science Research, National Institute of Radiological Sciences, Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba-shi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Quantum RedOx Chemistry Group, Institute for Quantum Life Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba-shi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhivko","family":"Zhelev","sequence":"additional","affiliation":[{"name":"Medical Faculty, Trakia University, Stara Zagora, Bulgaria."},{"name":"Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumiana","family":"Bakalova","sequence":"additional","affiliation":[{"name":"Functional and Molecular Imaging Goup, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba-shi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichio","family":"Aoki","sequence":"additional","affiliation":[{"name":"Functional and Molecular Imaging Goup, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba-shi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.07.016"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90116-0"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910100211"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.10.007"},{"key":"e_1_3_6_6_2","first-page":"109","article-title":"Contrast-induced nephropathy: epidemiology and prevention","volume":"54","author":"Bagshaw SM","year":"2006","unstructured":"Bagshaw SM, and Culleton BF. 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