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Healthy PVAT has anticontractile, anti-inflammatory, and antioxidative actions. Accumulating data from both human and experimental animal models indicate that PVAT dysfunction is conceivably coupled to cardiovascular diseases, and it is associated with vascular inflammation, oxidative stress, and arterial remodeling. Therefore, \u201chealthy\u201d PVAT may constitute a novel therapeutic target for the prevention and treatment of cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) has been recognized as a vascular anti-contractile factor released from PVAT. The enzymes deputed to H\n                      <jats:sub>2<\/jats:sub>\n                      S biosynthesis are variously expressed in PVAT and strictly dependent on the vascular bed and species. Metabolic and cardiovascular diseases can alter the morphological and secretory characteristics of PVAT, influencing also the H\n                      <jats:sub>2<\/jats:sub>\n                      S signaling. Here, we discuss the role of PVAT-derived H\n                      <jats:sub>2<\/jats:sub>\n                      S in healthy conditions and its relevance in alterations occurring in vascular disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      We discuss how a better understanding may help in the prevention of vascular dysfunction related to alteration in PVAT-released H\n                      <jats:sub>2<\/jats:sub>\n                      S as well as the importance of the interplay between PVAT and H\n                      <jats:sub>2<\/jats:sub>\n                      S.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      We propose future directions to evaluate the contribution of each enzyme involved in H\n                      <jats:sub>2<\/jats:sub>\n                      S biosynthesis and their alteration\/switch occurring in vascular disorders and the remaining challenges in investigating the role of H\n                      <jats:sub>2<\/jats:sub>\n                      S.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                      . 37, 84\u201397.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0147","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T10:19:05Z","timestamp":1650449945000},"page":"84-97","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Perivascular Adipose Tissue-Derived Hydrogen Sulfide in the Control of Vascular Homeostasis"],"prefix":"10.1177","volume":"37","author":[{"given":"Emma","family":"Mitidieri","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Turnaturi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Vanacore","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-5424","authenticated-orcid":false,"given":"Raffaella","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"d'Emmanuele di Villa Bianca","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP271006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12479"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12171"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0320-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0543"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152908783884920"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.12.004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.209783"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.02.014"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122886"},{"key":"e_1_3_3_13_2","first-page":"295","article-title":"The role of perivascular adipose tissue and endogenous hydrogen sulfide in vasoactive responses of isolated mesenteric arteries in normotensive and spontaneously hypertensive rats","volume":"70","author":"Cacanyiova S","year":"2019","unstructured":"Cacanyiova S, , Majzunova M, , Golas S, , and Berenyiova A. 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