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Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation, redox balance, and enzymatic actions. The interplay between H\n                      <jats:sub>2<\/jats:sub>\n                      S and iron metabolisms and functions impacts significantly on the fate and wellness of different types of cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      Iron level\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      affects the production of H\n                      <jats:sub>2<\/jats:sub>\n                      S\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      nonenzymatic reactions. On the contrary, H\n                      <jats:sub>2<\/jats:sub>\n                      S quenches excessive iron inside the cells and regulates the redox status of iron.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Abnormal metabolisms of both iron and H\n                      <jats:sub>2<\/jats:sub>\n                      S are associated with various conditions and diseases such as iron overload, anemia, oxidative stress, and cardiovascular and neurodegenerative diseases. The molecular mechanisms for the interactions between H\n                      <jats:sub>2<\/jats:sub>\n                      S and iron are unsettled yet. Here we review signaling links of the production, metabolism, and their respective and integrative functions of H\n                      <jats:sub>2<\/jats:sub>\n                      S and iron in normalcy and diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      Physiological and pathophysiological importance of H\n                      <jats:sub>2<\/jats:sub>\n                      S and iron as well as their therapeutic applications should be evaluated jointly, not separately. Future investigation should expand from iron-rich cells and tissues to the others, in which H\n                      <jats:sub>2<\/jats:sub>\n                      S and iron interaction has not received due attention.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      36, 275\u2013293.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0203","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:12:36Z","timestamp":1631182356000},"page":"275-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-4471","authenticated-orcid":false,"given":"Hassan Mustafa","family":"Arif","sequence":"first","affiliation":[{"name":"Department of Biology, York University, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Translational &amp; Precision Medicine, Nantong University, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-3620","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour N","year":"2014","unstructured":"Abbaspour N, , Hurrell R, , and Kelishadi R. 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