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Although reactive oxygen species (ROS) are crucial for sperm cell normal physiological processes, an imbalance between ROS production and antioxidants can lead to oxidative stress that can impair sperm function. Indeed, high semen ROS levels are reported in 30%\u201380% of infertile men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>Male oxidative stress infertility is an uprising classification for idiopathic infertility. Proteomic approaches, including quantitative mass spectrometry (MS)-based proteomics, are being utilized to explore the molecular mechanisms associated with oxidative stress in male infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>In this review, proteome data were collected from articles available on PubMed centered on MS-based proteomic studies, performed in seminal plasma and sperm cell samples, and enrolling men with impaired semen parameters. The bioinformatic analysis of proteome data with Cytoscape (ClueGO+CluePedia) and STRING tools allowed the identification of the biological processes more prevalent in asthenozoospermia, with focus on the ones related to oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      The identification of the antioxidant proteins in seminal plasma and sperm cells that can protect sperm cells from oxidative stress is crucial not only for a better understanding of the molecular mechanisms associated with male infertility but specially to guide new therapeutic possibilities.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      37, 501\u2013520.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0241","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:26:18Z","timestamp":1638321978000},"page":"501-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Exploring the Role of Oxidative Stress in Sperm Motility: A Proteomic Network Approach"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-8875","authenticated-orcid":false,"given":"Jo\u00e3o C.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Anatomy and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal."},{"name":"QOPNA &amp; LAQV, Department of Chemistry, University of Aveiro, Aveiro, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Nogueira-Ferreira","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Amado","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV, Department of Chemistry, University of Aveiro, Aveiro, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-783X","authenticated-orcid":false,"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV, Department of Chemistry, University of Aveiro, Aveiro, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"QOPNA &amp; LAQV, Department of Chemistry, University of Aveiro, Aveiro, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2019.20.1.79"},{"key":"e_1_3_6_3_2","first-page":"61","article-title":"Review on the role of glutathione on oxidative stress and infertility","volume":"22","author":"Adeoye O","year":"2018","unstructured":"Adeoye O, , Olawumi J, , Opeyemi A, , and Christiania O. 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