{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:35:27Z","timestamp":1790217327152,"version":"4.1.0"},"reference-count":149,"publisher":"SAGE Publications","issue":"4-6","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Significance:<\/jats:title>\n                    <jats:p>\n                      Acute responses to hypoxia are essential for the survival of mammals. The carotid body (CB), the main arterial chemoreceptor, contains glomus cells with oxygen (O\n                      <jats:sub>2<\/jats:sub>\n                      )-sensitive K\n                      <jats:sup>+<\/jats:sup>\n                      channels, which are inhibited during hypoxia to trigger adaptive cardiorespiratory reflexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>\n                      In this review, recent advances in molecular mechanisms of acute O\n                      <jats:sub>2<\/jats:sub>\n                      sensing in CB glomus cells are discussed, with a special focus on the signaling role of mitochondria through regulating cellular redox status. These advances have been achieved thanks to the use of genetically engineered redox-sensitive green fluorescent protein (roGFP) probes, which allowed us to monitor rapid changes in ROS production in real time in different subcellular compartments during hypoxia. This methodology was used in combination with conditional knockout mice models, pharmacological approaches, and transcriptomic studies. We have proposed a mitochondria-to-membrane signaling model of acute O\n                      <jats:sub>2<\/jats:sub>\n                      sensing in which H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      released in the mitochondrial intermembrane space serves as a signaling molecule to inhibit K\n                      <jats:sup>+<\/jats:sup>\n                      channels on the plasma membrane.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>\n                      Changes in mitochondrial reactive oxygen species (ROS) production during acute hypoxia are highly compartmentalized in the submitochondrial regions. The use of redox-sensitive probes targeted to specific compartments is essential to fully understand the role of mitochondrial ROS in acute O\n                      <jats:sub>2<\/jats:sub>\n                      sensing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>\n                      Further studies are needed to specify the ROS and to characterize the target(s) of ROS in chemoreceptor cells during acute hypoxia. These data may also contribute to a more complete understanding of the implication of ROS in acute responses to hypoxia in O\n                      <jats:sub>2<\/jats:sub>\n                      -sensing cells in other organs.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal<\/jats:italic>\n                      . 37, 274\u2013289.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2021.0255","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T09:49:25Z","timestamp":1642585765000},"page":"274-289","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Mitochondrial Redox Signaling in O\n                    <sub>2<\/sub>\n                    -Sensing Chemoreceptor Cells"],"prefix":"10.1177","volume":"37","author":[{"given":"Lin","family":"Gao","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ortega-S\u00e1enz","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Moreno-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-6095","authenticated-orcid":false,"given":"Jos\u00e9","family":"L\u00f3pez-Barneo","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain."},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.6.1100"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.5.1912"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.5.1903"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.009"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11871"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth866"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6019"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1280617"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.01.003"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.04.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2020.1828258"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp021890"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.257741"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020143"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.3.1317"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.13.1719"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00317-8"},{"key":"e_1_3_4_19_2","first-page":"51","article-title":"Redox-sensitive green fluorescent protein: probes for dynamic intracellular redox responses. 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