{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:32Z","timestamp":1787008172977,"version":"build-2736575974"},"reference-count":9,"publisher":"SAGE Publications","issue":"1-3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Over the past decade, extensive research has been dedicated to understanding oxidative cell death, specifically the transition from oxytosis to ferroptosis. Oxytosis was initially characterized in 1989 as a calcium-dependent form of nerve cell death induced by glutamate. It was associated with intracellular glutathione depletion and the inhibition of cystine uptake through system xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    , a cystine\u2013glutamate antiporter. In 2012, the term \u201cferroptosis\u201d was coined during a compound screening that aimed to selectively induce cell death in\n                    <jats:italic toggle=\"yes\">RAS<\/jats:italic>\n                    -mutated cancer cells. This screening identified erastin and RSL3 as inhibitors of system xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    and glutathione peroxidase 4 (GPX4), respectively, triggering oxidative cell death. Subsequently, the term oxytosis gradually fell out of frequent usage, being replaced by ferroptosis. This editorial provides a narrative review of the significant findings, experimental models, and molecular players involved in ferroptosis, shedding light on its intricate mechanisms. Moreover, it discusses the implications of these findings in various pathological conditions, including neurodegenerative disorders, cancer, and ischemia\u2013reperfusion disease. By summarizing the decade-long progress made in this field, the present Forum serves as a valuable resource for researchers aiming to unravel the complex mechanisms underlying oxidative cell death and explore potential therapeutic interventions.\n                    <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                    39, 162\u2013165.\n                  <\/jats:p>","DOI":"10.1089\/ars.2023.0356","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:55:47Z","timestamp":1686207347000},"page":"162-165","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["From Oxytosis to Ferroptosis: 10 Years of Research on Oxidative Cell Death"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-6180","authenticated-orcid":false,"given":"Daolin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-197X","authenticated-orcid":false,"given":"Rui","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0202"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0007"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1187366"},{"key":"e_1_3_4_5_1","first-page":"10","article-title":"Striking a NRF2: The rusty and rancid vulnerabilities toward ferroptosis in Alzheimer's disease","author":"Lane DJR","year":"2023","unstructured":"Lane DJR, , Alves F, , Ayton S, et al. Striking a NRF2: The rusty and rancid vulnerabilities toward ferroptosis in Alzheimer's disease. Antioxid Redox Signal, 2023; doi: 10.1089\/ars.2023.0318","journal-title":"Antioxid Redox Signal"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35707-2"},{"key":"e_1_3_4_7_1","first-page":"10","article-title":"SLC25A22 as a key mitochondrial transporter against ferroptosis by producing GSH and MUFAs","author":"Liu Y","year":"2023","unstructured":"Liu Y, , Wang Y, , Lin Z, et al. SLC25A22 as a key mitochondrial transporter against ferroptosis by producing GSH and MUFAs. Antioxid Redox Signal, 2023; doi: 10.1089\/ars.2022.0203","journal-title":"Antioxid Redox Signal"},{"key":"e_1_3_4_8_1","first-page":"10","article-title":"Dynamic regulation of ferroptosis by lipid metabolism","author":"Naowarojna N","year":"2023","unstructured":"Naowarojna N, , Wu TW, , Pan Z, et al. Dynamic regulation of ferroptosis by lipid metabolism. Antioxid Redox Signal, 2023; doi: 10.1089\/ars.2023.0278","journal-title":"Antioxid Redox Signal"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026013394741"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ars.2023.0356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2023.0356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ars.2023.0356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:23Z","timestamp":1777377323000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ars.2023.0356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":9,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1089\/ars.2023.0356"],"URL":"https:\/\/doi.org\/10.1089\/ars.2023.0356","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}