{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:09:10Z","timestamp":1788260950774,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"4-6","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      In addition to reducing the respiratory function, crystalline silica (SiO\n                      <jats:sub>2<\/jats:sub>\n                      ) disturbs the immune response by affecting immune cells during the progression of silicosis. Regulatory T cell (Treg) differentiation may play a key role in the abnormal polarization of T helper cell (Th)1 and Th2 cells in the development of silicosis-induced fibrosis. Alpha-lipoic acid (ALA) has immunomodulatory effects by promoting Tregs differentiation. Thus, ALA may have a therapeutic potential for treating autoimmune disorders in patients with silicosis. However, little is known regarding whether ALA regulates the immune system during silicosis development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found that the expression levels of collagen increased, and the antioxidant capacity was lower in the\n                      <jats:italic toggle=\"yes\">\n                        Lias\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      +SiO\n                      <jats:sub>2<\/jats:sub>\n                      group than in the\n                      <jats:italic toggle=\"yes\">Lias<\/jats:italic>\n                      <jats:sup>\n                        +\n                        <jats:italic toggle=\"yes\">\/+<\/jats:italic>\n                      <\/jats:sup>\n                      +SiO\n                      <jats:sub>2<\/jats:sub>\n                      group. The proportion of Tregs decreased in the peripheral blood and spleen tissue in mice exposed to SiO\n                      <jats:sub>2<\/jats:sub>\n                      . The proportion of Tregs in the\n                      <jats:italic toggle=\"yes\">\n                        Lias\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      +SiO\n                      <jats:sub>2<\/jats:sub>\n                      group was significantly lower than that in the\n                      <jats:italic toggle=\"yes\">\n                        Lias\n                        <jats:sup>+\/+<\/jats:sup>\n                      <\/jats:italic>\n                      +SiO\n                      <jats:sub>2<\/jats:sub>\n                      group. Supplementary exogenous ALA attenuates the accumulation of inflammatory cells and extracellular matrix in lung tissues. ALA promotes the immunological balance between Th17 and Treg responses during the development of silicosis-induced fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our findings confirmed that low expression of lipoic acid synthase aggravates SiO\n                      <jats:sub>2<\/jats:sub>\n                      -induced silicosis, and that supplementary exogenous ALA has therapeutic potential by improving Tregs in silicosis fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ars.2023.0387","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T02:39:46Z","timestamp":1702003186000},"page":"216-232","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Low Expression of Lipoic Acid Synthase Aggravates Silica-Induced Pulmonary Fibrosis by Inhibiting the Differentiation of Tregs in Mice"],"prefix":"10.1177","volume":"41","author":[{"given":"Sensen","family":"Yan","sequence":"first","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-4351","authenticated-orcid":false,"given":"Yingzheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabo","family":"Guan","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Lyu","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcui","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanqiao","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.001"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.08.014"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8ra03970d"},{"issue":"4","key":"e_1_3_4_5_1","first-page":"406","article-title":"Responses of male C57BL\/6N mice to observing the euthanasia of other mice","volume":"55","author":"Boivin GP","year":"2016","unstructured":"Boivin GP, , Bottomley MA, , Grobe N. 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